Laboratory for Vascular Medicine and Stem Cell Biology, Medical Research Institute, Department of Physiology, School of Medicine, Pusan National University, Yangsan 50612, Korea.
Convergence Stem Cell Research Center, Pusan National University, Yangsan 50612, Korea.
Int J Mol Sci. 2018 Mar 22;19(4):949. doi: 10.3390/ijms19040949.
Peroxisome proliferator-activated receptors (PPARs), members of the nuclear receptor superfamily, are important in whole-body energy metabolism. PPARs are classified into three isoforms, namely, PPARα, β/δ, and γ. They are collectively involved in fatty acid oxidation, as well as glucose and lipid metabolism throughout the body. Importantly, the three isoforms of PPARs have complementary and distinct metabolic activities for energy balance at a cellular and whole-body level. PPARs also act with other co-regulators to maintain energy homeostasis. When endogenous ligands bind with these receptors, they regulate the transcription of genes involved in energy homeostasis. However, the exact molecular mechanism of PPARs in energy metabolism remains unclear. In this review, we summarize the importance of PPAR signals in multiple organs and focus on the pivotal roles of PPAR signals in cellular and whole-body energy homeostasis.
过氧化物酶体增殖物激活受体 (PPARs) 是核受体超家族的成员，在全身能量代谢中起着重要作用。PPARs 分为三种亚型，即 PPARα、β/δ 和 γ。它们共同参与脂肪酸氧化以及全身的葡萄糖和脂质代谢。重要的是，三种 PPAR 亚型在细胞和全身水平上对能量平衡具有互补且独特的代谢活性。PPARs 还与其他共调节因子一起作用以维持能量平衡。当内源性配体与这些受体结合时，它们会调节参与能量平衡的基因的转录。然而，PPARs 在能量代谢中的确切分子机制尚不清楚。在这篇综述中，我们总结了 PPAR 信号在多个器官中的重要性，并重点介绍了 PPAR 信号在细胞和全身能量平衡中的关键作用。
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