Degrading proteins in animals: "PROTAC"tion goes in vivo.
作者信息
Guo Jianping, Liu Jing, Wei Wenyi
机构信息
The First Affiliated Hospital, Sun Yat-sen University, 510275, Guangzhou, Guangdong, China.
Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.
出版信息
Cell Res. 2019 Mar;29(3):179-180. doi: 10.1038/s41422-019-0144-9.
Abstract
摘要
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本文引用的文献
1
Drugging the 'undruggable' cancer targets.针对“不可成药”的癌症靶点研发药物。
Nat Rev Cancer. 2017 Aug;17(8):502-508. doi: 10.1038/nrc.2017.36. Epub 2017 Jun 23.
2
DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation.药物研发。邻苯二甲酰亚胺缀合作为体内靶蛋白降解的一种策略。
Science. 2015 Jun 19;348(6241):1376-81. doi: 10.1126/science.aab1433. Epub 2015 May 21.
3
Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide.与沙利度胺结合的DDB1-CRBN E3泛素连接酶的结构。
Nature. 2014 Aug 7;512(7512):49-53. doi: 10.1038/nature13527. Epub 2014 Jul 16.
4
Multiplex genome engineering using CRISPR/Cas systems.利用 CRISPR/Cas 系统进行多重基因组工程。
Science. 2013 Feb 15;339(6121):819-23. doi: 10.1126/science.1231143. Epub 2013 Jan 3.
5
Protacs for treatment of cancer.蛋白水解靶向嵌合体用于癌症治疗。
Pediatr Res. 2010 May;67(5):505-8. doi: 10.1203/PDR.0b013e3181d35017.
6
RNAi therapeutics: a potential new class of pharmaceutical drugs.RNA干扰疗法：一类潜在的新型药物。
Nat Chem Biol. 2006 Dec;2(12):711-9. doi: 10.1038/nchembio839.
7
Chemical genetic control of protein levels: selective in vivo targeted degradation.蛋白质水平的化学遗传学控制：体内选择性靶向降解
J Am Chem Soc. 2004 Mar 31;126(12):3748-54. doi: 10.1021/ja039025z.
8
Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy.雌激素可保护FKBP12.6基因敲除小鼠免于心脏肥大。
Nature. 2002 Mar 21;416(6878):334-8. doi: 10.1038/416334a.
9
Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation.蛋白酶靶向嵌合体（PROTACs）：将蛋白质靶向Skp1-Cullin-F盒复合物进行泛素化和降解的嵌合分子。
Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8554-9. doi: 10.1073/pnas.141230798. Epub 2001 Jul 3.
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