Mielle Julie, Tison Alice, Cornec Divi, Le Pottier Laëtitia, Daien Claire, Pers Jacques-Olivier
Departement of Rheumatology, UMR5535, Inflammation and Cancer, University of Montpellier and Teaching hospital of Montpellier, Montpellier, France.
UMR1227, Lymphocytes B et Autoimmunité, Université de Brest, Inserm, France.
Rheumatology (Oxford). 2021 Jun 18;60(6):2545-2560. doi: 10.1093/rheumatology/key332.
Biological abnormalities associated with B lymphocytes are a hallmark of patients with primary Sjögren's syndrome. Those patients present abnormal distribution of B lymphocytes in peripheral blood and B cells in exocrine glands. B cells produce auto-antibodies, cytokines and present antigens but can also suppressive functions. In this review, we will summarize current knowledge on B cells in primary Sjögren's syndrome patients, demonstrate their critical role in the immunopathology of the disease and describe the past and current trials targeting B cells.
与B淋巴细胞相关的生物学异常是原发性干燥综合征患者的一个标志。这些患者外周血中的B淋巴细胞和外分泌腺中的B细胞分布异常。B细胞产生自身抗体、细胞因子并呈递抗原，但也具有抑制功能。在本综述中，我们将总结原发性干燥综合征患者B细胞的现有知识，证明它们在该疾病免疫病理学中的关键作用，并描述过去和当前针对B细胞的试验。
