非编码RNA在干燥综合征发病机制中的作用

Role of ncRNAs in the Pathogenesis of Sjögren's Syndrome.

作者信息

Al-Haidose Amal, Hassan Sondoss, Elhassan Mahmoud, Ahmed Eiman, Al-Riashi Abdulla, Alharbi Yazeed M, Ghunaim Monther, Alhejaili Talal, Abdallah Atiyeh M

机构信息

Department of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha 2713, Qatar.

Department of Internal Medicine, Collage of Medicine, Taibah University, Madinah 42353, Saudi Arabia.

出版信息

Biomedicines. 2024 Jul 11;12(7):1540. doi: 10.3390/biomedicines12071540.

DOI:10.3390/biomedicines12071540

PMID:39062113

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11274537/

Abstract

Sjögren's syndrome is a multisystemic autoimmune disease that mainly affects the exocrine glands, causing dryness of the eyes and the mouth as the principal symptoms. Non-coding RNAs (ncRNAs), once regarded as genomic "junk", are now appreciated as important molecular regulators of gene expression, not least in Sjögren's syndrome and other autoimmune diseases. Here we review research into the causative roles of microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) on immunological responses, inflammation, and salivary gland epithelial cell function in Sjögren's syndrome patients. These ncRNAs represent promising new therapeutic targets for treating the disease and possibly as biomarkers for early diagnosis.

摘要

干燥综合征是一种多系统自身免疫性疾病，主要影响外分泌腺，导致眼睛和口腔干燥为主要症状。非编码RNA（ncRNAs），曾被视为基因组“垃圾”，现在被认为是基因表达的重要分子调节因子，尤其是在干燥综合征和其他自身免疫性疾病中。在这里，我们综述了关于微小RNA（miRNAs）、长链非编码RNA（lncRNAs）和环状RNA（circRNAs）在干燥综合征患者免疫反应、炎症和唾液腺上皮细胞功能中的致病作用的研究。这些ncRNAs代表了治疗该疾病有前景的新治疗靶点，也可能作为早期诊断的生物标志物。