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人类终纹床核中 nesfatin-1 表达神经元的首次鉴定。

The first identification of nesfatin-1-expressing neurons in the human bed nucleus of the stria terminalis.

机构信息

Department of Histology, School of Medicine in Katowice, Medical University of Silesia, ul. Medyków 18, 40-752, Katowice, Poland.

Department of Anatomy, School of Medicine in Katowice, Medical University of Silesia, ul. Medyków 18, 40-752, Katowice, Poland.

出版信息

J Neural Transm (Vienna). 2019 Mar;126(3):349-355. doi: 10.1007/s00702-019-01984-3. Epub 2019 Feb 15.

DOI:10.1007/s00702-019-01984-3
PMID:30770997
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6449486/
Abstract

Neuropeptides are involved in various brain activities being able to control a wide spectrum of higher mental functions. The purpose of this concise structural investigation was to detect the possible immunoreactivity of the novel multifunctional neuropeptide nesfatin-1 within the human bed nucleus of the stria terminalis (BNST). The BNST is involved in the mechanism of fear learning, integration of stress and reward circuits, and pathogenesis of addiction. Nesfatin-1-expressing neurons were identified for the first time in several regions of the BNST using both immunohistochemical and fluorescent methods. This may implicate a potential contribution of this neuropeptide to the BNST-related mechanisms of stress/reward responses in the human brain.

摘要

神经肽参与各种大脑活动，能够控制广泛的高级心理功能。本简明结构研究的目的是检测新型多功能神经肽 nesfatin-1 在人类终纹床核（BNST）内的可能免疫反应性。BNST 参与恐惧学习、应激和奖励回路的整合以及成瘾的发病机制。首次使用免疫组织化学和荧光方法在 BNST 的几个区域中鉴定出表达 nesfatin-1 的神经元。这可能暗示这种神经肽可能对人类大脑中与 BNST 相关的应激/奖励反应机制有潜在贡献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8fa/6449486/aed45842359d/702_2019_1984_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8fa/6449486/02e6622a50fc/702_2019_1984_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8fa/6449486/aed45842359d/702_2019_1984_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8fa/6449486/02e6622a50fc/702_2019_1984_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8fa/6449486/aed45842359d/702_2019_1984_Fig2_HTML.jpg

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