对Nesfatin-1作用的当前认识。
Current Understanding of the Role of Nesfatin-1.
作者信息
Schalla Martha A, Stengel Andreas
机构信息
Charité Center for Internal Medicine and Dermatology, Department for Psychosomatic Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin.
Department of Psychosomatic Medicine and Psychotherapy, Medical University Hospital Tübingen, 72076 Tübingen, Germany.
出版信息
J Endocr Soc. 2018 Sep 10;2(10):1188-1206. doi: 10.1210/js.2018-00246. eCollection 2018 Oct 1.
Nesfatin-1 was discovered in 2006 and implicated in the regulation of food intake. Subsequently, its widespread central and peripheral distribution gave rise to additional effects. Indeed, a multitude of actions were described, including modulation of gastrointestinal functions, glucose and lipid metabolism, thermogenesis, mediation of anxiety and depression, as well as cardiovascular and reproductive functions. Recent years have witnessed a great increase in our knowledge of these effects and their underlying mechanisms, which will be discussed in the present review. Lastly, gaps in knowledge will be highlighted to foster further studies.
内脂素-1于2006年被发现，并与食物摄入的调节有关。随后，其在中枢和外周广泛分布产生了其他作用。事实上，人们描述了它的多种作用，包括调节胃肠功能、葡萄糖和脂质代谢、产热、介导焦虑和抑郁，以及心血管和生殖功能。近年来，我们对这些作用及其潜在机制的认识有了很大提高，本综述将对此进行讨论。最后，将强调知识空白以促进进一步研究。
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