Kim Christina S, Claud Erika C
Neonatology, Department of Pediatrics, University of Chicago, 5841 South Maryland Avenue, MC 6060, Chicago, IL 60637, USA.
Neonatology, Department of Pediatrics, University of Chicago, 5841 South Maryland Avenue, MC 6060, Chicago, IL 60637, USA.
Clin Perinatol. 2019 Mar;46(1):29-38. doi: 10.1016/j.clp.2018.10.003. Epub 2018 Dec 12.
Necrotizing enterocolitis is a major cause of mortality and morbidity in the preterm infant population. The gut microbiome is of particular interest in research surrounding necrotizing enterocolitis, because variations in the intestinal microbiota seem to correlate with the risk of inflammation and disease. Recent advances in non-culture-based genomic sequencing have also allowed for more intricate analyses of the intestinal microbiome. Its evolution seems to be influenced by intrauterine and extrauterine factors, ranging from antenatal antibiotic exposure to type of enteral feeds. Ultimately, these alterations in the gut microbiome have the potential to result in devastating diseases like necrotizing enterocolitis.
坏死性小肠结肠炎是早产婴儿群体中导致死亡和发病的主要原因。在围绕坏死性小肠结肠炎的研究中，肠道微生物群特别受关注，因为肠道微生物群的变化似乎与炎症和疾病风险相关。基于非培养的基因组测序技术的最新进展也使得对肠道微生物群进行更精细的分析成为可能。其演变似乎受宫内和宫外多种因素影响，从产前抗生素暴露到肠内喂养类型等。最终，肠道微生物群的这些改变有可能导致像坏死性小肠结肠炎这样的毁灭性疾病。
