Institute of Microbiology, Lausanne University Hospital and Lausanne University, Switzerland.
Infectious Diseases Service, Department of Medicine, Lausanne University Hospital and Lausanne University, Switzerland.
Int J Infect Dis. 2019 Apr;81:167-169. doi: 10.1016/j.ijid.2019.02.001. Epub 2019 Feb 14.
We describe here a rare case of septic pseudarthrosis due to Erysipelatoclostridium ramosum in a female young patient. The patient, currently in remission from Ewing's sarcoma treated by a bone resection and allograft combined with chemotherapy, suffered from a chronic femoral pseudarthrosis in a context of bone insufficiency and graft resorption. A broad range 16S PCR followed by sequencing, as well as an enrichment culture of a bone biopsy revealed the presence of E. ramosum, an anaerobic firmicute with a low Gram-positive affinity staining and low GC content, that was further characterized by whole genome sequencing (WGS).
我们在此描述了一例年轻女性由红斑丹毒丝菌引起的感染性假关节形成的罕见病例。该患者目前患有尤文肉瘤，已通过骨切除和同种异体骨移植联合化疗缓解，在骨量不足和移植物吸收的情况下患有慢性股骨假关节形成。广泛的 16S PCR 测序，以及骨活检的富集培养，显示存在红斑丹毒丝菌，一种厌氧菌，革兰氏阳性染色亲和力低，GC 含量低，进一步通过全基因组测序（WGS）进行了特征描述。
