Bao Danni, Xu Xiaohong, Wang Yizhang, Zhu Fengjiao, Wu Yanhong, Li Hongzhang
Department of Clinical Laboratory, Sanmen People's Hospital, Taizhou, Zhejiang, People's Republic of China.
Department of Gastroenterology, Sanmen People's Hospital, Taizhou, Zhejiang, People's Republic of China.
Infect Drug Resist. 2023 Jul 8;16:4455-4461. doi: 10.2147/IDR.S421409. eCollection 2023.
We report a case of bacteremia in a 73-year-old patient with SARS-CoV-2 infection and right lower abdominal tenderness in China. The microbiological features and genomic epidemiological characteristics of worldwide were investigated to identify the possible sources of infection. Whole-genome sequencing of WD-I2 was performed using an Illumina NovaSeq 6000 platform. Phylogenetic analysis of WD-I2 and other publicly available isolates was performed and visualized using the interactive Tree of Life (iTOL) web server. The resistome of WD-I2 consists of two antimicrobial resistance genes (M and B), which explains the antimicrobial resistance trait to tetracycline and macrolides. Phylogenetic analysis showed that the strain closest to our isolated strain WD-I2 was SUG1069, recovered from a pig feces sample from Canada, which differed by 589 SNPs. To our knowledge, this is the first report of bacteremia in China. Our findings highlight the potential risk of invasive infections during the COVID-19 pandemic.
我们报告了中国一名73岁的新冠病毒感染患者发生菌血症且伴有右下腹部压痛的病例。对全球范围内的微生物学特征和基因组流行病学特征进行了调查，以确定可能的感染源。使用Illumina NovaSeq 6000平台对WD-I2进行全基因组测序。使用交互式生命树（iTOL）网络服务器对WD-I2和其他公开可用的分离株进行系统发育分析并可视化。WD-I2的耐药基因组由两个抗菌抗性基因（M和B）组成，这解释了其对四环素和大环内酯类抗生素的耐药特性。系统发育分析表明，与我们分离的菌株WD-I2最接近的菌株是从加拿大猪粪便样本中分离出的SUG1069，两者相差589个单核苷酸多态性（SNP）。据我们所知，这是中国首例菌血症报告。我们的研究结果突出了新冠疫情期间侵袭性感染的潜在风险。
