a Student Research Committee, Department of Immunology, School of Medicine , Mazandaran University of Medical Sciences , Sari , Iran.
b Department of Immunology, School of Medicine , Mazandaran University of Medical Sciences , Sari , Iran.
Infect Dis (Lond). 2019 May;51(5):321-333. doi: 10.1080/23744235.2019.1568545. Epub 2019 Feb 18.
Brucellosis, caused by the intracellular pathogens Brucella, is one of the major zoonotic infections. Considering the economic burden, its prevalence has been a health concern especially in endemic regions. Brucella is able to survive and replicate within host cells by expressing different virulence factors and using various strategies to avoid the host's immune response. This leads to progression of the disease from an acute phase to chronic brucellosis. Exploration of genetic variations has confirmed the expected influence of gene polymorphisms on susceptibility and resistance to brucellosis of humans. Since there is no approved human vaccine and treatment is uncertain with risk of relapse, it is important to increase knowledge about pathogenesis, diagnosis and treatment of brucellosis in order to manage and control this infection, especially in endemic regions.
布鲁氏菌病是由细胞内病原体布鲁氏菌引起的一种主要的人畜共患病。考虑到经济负担，其流行一直是一个健康问题，特别是在流行地区。布鲁氏菌通过表达不同的毒力因子和使用各种策略来逃避宿主的免疫反应，从而在宿主细胞内存活和复制。这导致疾病从急性阶段进展为慢性布鲁氏菌病。遗传变异的探索证实了基因多态性对人类布鲁氏菌病易感性和抵抗力的预期影响。由于没有批准的人类疫苗，治疗存在复发风险，因此了解布鲁氏菌病的发病机制、诊断和治疗对于管理和控制这种感染非常重要，特别是在流行地区。
