Martínez-Suárez J V, Baquero F
Servicio de Microbiología, Hospital Ramón y Cajal, Madrid.
Microbiologia. 1987 Oct;3(3):149-62.
Current problems of antibiotic resistance in the Bacteroides fragilis group are reviewed. The original susceptibility (before 1976) of this group of strict anaerobic microorganisms to some beta-lactams, tetracyclines and lincosamides is presently severely damaged, and new mechanisms of resistance, such the enzymatic inactivation of chloramphenicol, seem to arise. Conjugative transfer of chromosomal resistance genes appears to be the main strategy for the spread of resistance and in various cases plasmids are involved. The origin of such resistance genes remains obscure. There is a possibility of gene exchange between Bacteroides and Enterobacteriaceae, but there are problems of plasmid maintenance and/or gene expression. In some cases a striking homology of the Bacteroides resistance determinants with those of Gram-positive organisms can be documented.
本文综述了脆弱拟杆菌群中当前的抗生素耐药性问题。这类严格厌氧微生物最初（1976年以前）对某些β-内酰胺类、四环素类和林可酰胺类药物敏感，目前这种敏感性已严重受损，并且似乎出现了新的耐药机制，如氯霉素的酶失活。染色体耐药基因的接合转移似乎是耐药性传播的主要策略，在各种情况下都涉及质粒。此类耐药基因的起源仍不清楚。拟杆菌与肠杆菌科之间存在基因交换的可能性，但存在质粒维持和/或基因表达的问题。在某些情况下，可以证明拟杆菌耐药决定簇与革兰氏阳性菌的耐药决定簇具有显著的同源性。
