School of Chemical Engineering, College of Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Natural Product Informatics Research Center, Korea Institute of Science and Technology, Gangneung, 25451, Republic of Korea.
Adv Mater. 2019 Aug;31(34):e1803549. doi: 10.1002/adma.201803549. Epub 2019 Feb 18.
There is a rapidly increasing interest in developing stimuli-responsive nanomaterials for treating a variety of diseases. By enabling the activation of function locally at the sites of interest, it is possible to increase therapeutic efficacy significantly while simultaneously reducing adverse side effects. While there are many sophisticated nanomaterials available, they are often highly complex and not easily transferrable to industrial scales and clinical settings. However, nanomaterials based on hyaluronic acid offer a compelling strategy for reducing their complexity while retaining several desirable benefits such as active targeting and stimuli-responsive degradation. Herein, the basic properties of hyaluronic acid, its binding partners, and natural routes for degradation by hyaluronidases-hyaluronic-acid-degrading enzymes-and oxidative stresses are discussed. Recent advances in designing hyaluronic acid-based, actively targeted, hyaluronidase- or reactive-oxygen-species-responsive nanomaterials for both diagnostic imaging and therapeutic delivery, which go beyond merely the classical targeting of CD44, are summarized.
人们对开发用于治疗各种疾病的响应性纳米材料越来越感兴趣。通过能够在感兴趣的部位局部激活功能，可以显著提高治疗效果，同时减少不良反应。虽然有许多复杂的纳米材料可用，但它们往往非常复杂，不容易转移到工业规模和临床环境中。然而，基于透明质酸的纳米材料提供了一种有吸引力的策略，可以降低其复杂性，同时保留一些理想的益处，如主动靶向和响应性降解。本文讨论了透明质酸的基本性质、与其结合的配体，以及透明质酸酶-透明质酸降解酶和氧化应激自然降解的途径。总结了近年来在设计基于透明质酸的主动靶向、透明质酸酶或活性氧物质响应性纳米材料用于诊断成像和治疗输送方面的进展，这些进展超出了仅仅针对 CD44 的经典靶向。
