基于透明质酸的纳米载体用于细胞内靶向：与癌症中蛋白质的界面相互作用。
Hyaluronic acid-based nanocarriers for intracellular targeting: interfacial interactions with proteins in cancer.
机构信息
Purdue University, Department of Biomedical Engineering, West Lafayette, IN 47907, USA.
出版信息
Colloids Surf B Biointerfaces. 2012 Nov 1;99:82-94. doi: 10.1016/j.colsurfb.2011.10.029. Epub 2011 Oct 20.
Abstract
The therapeutic efficacy of most drugs is greatly depends on their ability to cross the cellular barrier and reach their intracellular target sites. To transport the drugs effectively through the cellular membrane and to deliver them into the intracellular environment, several interesting smart carrier systems based on both synthetic or natural polymers have been designed and developed. In recent years, hyaluronic acid (HA) has emerged as a promising candidate for intracellular delivery of various therapeutic and imaging agents because of its innate ability to recognize specific cellular receptors that overexpressed on diseased cells. The aim of this review is to highlight the significance of HA in cancer, and to explore the recent advances of HA-based drug carriers towards cancer imaging and therapeutics.
摘要
大多数药物的治疗效果在很大程度上取决于它们穿过细胞屏障并到达细胞内靶位的能力。为了有效地将药物穿过细胞膜并递送到细胞内环境中，已经设计和开发了几种基于合成或天然聚合物的有趣的智能载体系统。近年来，透明质酸（HA）因其能够识别在病变细胞上过表达的特定细胞受体的固有能力，已成为递各种治疗和成像剂进入细胞内的有前途的候选物。本文综述的目的是强调 HA 在癌症中的重要性，并探讨基于 HA 的药物载体在癌症成像和治疗方面的最新进展。
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