Effects of exercise intervention on arterial stiffness in middle-aged and older females: evaluation by measuring brachial-ankle pulse wave velocity and cardio-ankle vascular index.

[Purpose] Brachial-ankle pulse wave velocity (baPWV) and cardio-ankle vascular index (CAVI) are simple, accurate, and reproducible indices of arterial stiffness. However, only a few studies have evaluated the influence of exercise-training baPWV and CAVI on arterial stiffness. Thus, this study aimed to examine the influence of aerobic-training baPWV and CAVI on arterial stiffness. [Participants and Methods] The participants were 20 middle-aged females (age, 60.1 ± 1.6 years) who were sedentary non-smokers. The participants underwent an exercise intervention, including a 50-min session of moderate-intensity exercises two or three times a week for 12 weeks. Blood pressure (BP), baPWV, and CAVI were measured before and after exercise. Blood nitrite/nitrate (NOx) was also measured as an index of vascular endothelial function. [Results] BaPWV significantly decreased after exercise, whereas CAVI and blood NOx did not change significantly after exercise. A significant correlation was observed between the decrease in baPWV and systolic BP after exercise. In addition, the participants with higher systolic BP before exercise showed a greater decrease in baPWV after exercise. [Conclusion] These results suggest that BP has a significant role in decreasing arterial stiffness after exercise. Further studies are required to elucidate the similarities and differences between baPWV and CAVI to use them more effectively as assessment parameters for arterial stiffness.