心血管踝肱指数与肱踝脉搏波速度相比，与糖尿病患者的动脉损伤和心血管疾病风险的相关性更密切。

Cardio-ankle vascular index is more closely associated than brachial-ankle pulse wave velocity with arterial damage and risk of cardiovascular disease in patients with diabetes.

机构信息

Division of Diabetes and Metabolic Diseases, Department of Internal Medicine, Nihon University School of Medicine, 30-1 Oyaguchikami-cho, Itabashi-ku, 173-8610, Tokyo, Japan.

Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, 2-2-2 Iida-nishi, 990-9585, Yamagata, Japan.

出版信息

BMC Cardiovasc Disord. 2022 Aug 9;22(1):365. doi: 10.1186/s12872-022-02800-9.

DOI:10.1186/s12872-022-02800-9

PMID:35945498

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9364514/

Abstract

BACKGROUND

This study aimed to compare the usefulness of arterial stiffness parameters, cardio-ankle vascular index (CAVI) and brachial-ankle pulse wave velocity (baPWV), for evaluating arterial damage and risk of cardiovascular disease (CVD) in subjects with diabetes.

METHODS

The study subjects were 277 patients with type 1 or type 2 diabetes. All subjects were evaluated for vascular stiffness using CAVI (n = 154) or baPWV (n = 123). Carotid intima-media thickness (IMT) and the Suita score were also measured because these are established risk factors for future CVD. Associations of both CAVI and baPWV with these established parameters were evaluated in all subjects, and then in 174 subjects with adjustment for covariates by using propensity score matching.

RESULTS

In all subjects, CAVI and baPWV correlated significantly with both IMT (r = 0.462, P < 0.001, and r = 0.212, P = 0.019, respectively) and the Suita score (r = 0.573, P < 0.001, and r = 0.373, P < 0.001, respectively). The correlation between CAVI and IMT was more significant than that between baPWV and IMT (Z = 2.33, P = 0.020). Similarly, the correlation between CAVI and the Suita score was more significant than that between baPWV and the Suita score (Z = 2.13, P = 0.033). After adjustment by propensity score matching, significant correlations between CAVI and IMT (r = 0.432 P < 0.001) and between CAVI and the Suita score (r = 0.544, P < 0.001) were preserved, though only the association between baPWV and the Suita score was significant (r = 0.289, P = 0.007) while that between baPWV and IMT showed no significance. Again, CAVI showed a significant association with the Suita score than baPWV (Z = 2.02, P = 0.043).

CONCLUSIONS

CAVI is more closely associated than baPWV with arterial damage and risk of CVD in patients with diabetes.

摘要

背景

本研究旨在比较动脉僵硬度参数，包括心血管踝臂指数（CAVI）和臂踝脉搏波速度（baPWV），在评估糖尿病患者的动脉损伤和心血管疾病（CVD）风险方面的作用。

方法

本研究的受试者为 277 例 1 型或 2 型糖尿病患者。所有受试者均采用 CAVI（n=154）或 baPWV（n=123）评估血管僵硬度。还测量了颈动脉内膜中层厚度（IMT）和 Suita 评分，因为它们是未来 CVD 的既定危险因素。在所有受试者中评估了 CAVI 和 baPWV 与这些既定参数的相关性，然后在 174 例经倾向评分匹配调整协变量的受试者中进行了评估。

结果

在所有受试者中，CAVI 和 baPWV 与 IMT（r=0.462，P<0.001 和 r=0.212，P=0.019）和 Suita 评分（r=0.573，P<0.001 和 r=0.373，P<0.001）均呈显著相关。CAVI 与 IMT 的相关性比 baPWV 与 IMT 的相关性更显著（Z=2.33，P=0.020）。同样，CAVI 与 Suita 评分的相关性比 baPWV 与 Suita 评分的相关性更显著（Z=2.13，P=0.033）。经过倾向评分匹配调整后，CAVI 与 IMT（r=0.432，P<0.001）和 CAVI 与 Suita 评分（r=0.544，P<0.001）之间仍存在显著相关性，而 baPWV 与 Suita 评分（r=0.289，P=0.007）之间的相关性仍然显著，而 baPWV 与 IMT 之间的相关性则不显著。同样，CAVI 与 Suita 评分的相关性也比 baPWV 更显著（Z=2.02，P=0.043）。