Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University, Kagoshima, Japan.
Circ J. 2011;75(3):698-702. doi: 10.1253/circj.cj-10-0552. Epub 2010 Dec 24.
The brachial-ankle pulse wave velocity (baPWV) and cardio-ankle vascular index (CAVI) are used to evaluate arterial distensibility. The purpose of this study was to elucidate the acute and chronic effects of smoking on arterial stiffness as measured by baPWV and CAVI.
Ten male smokers were studied to evaluate the acute effect of smoking on arterial stiffness. To elucidate the chronic effect of smoking on arterial stiffness, 160 male active smokers were analyzed. CAVI and baPWV were calculated by measuring the pulse volume record, blood pressure (BP), and vascular length from heart to ankle. CAVI and baPWV were measured using a VaSera VS-1000. In the acute study, baPWV and CAVI increased immediately after smoking 1 cigarette. In the chronic study, baPWV and CAVI significantly correlated with mean BP (MBP) and the Brinkman index. In multiple regression analysis, baPWV independently correlated with MBP, and CAVI independently correlated with the Brinkman index, but not with MBP. Receiver-operating characteristics (ROC) curves of baPWV and CAVI to predict Brinkman index ≥500 demonstrated that the area under the ROC curve of CAVI was higher than that of baPWV.
Smoking causes a significant increase in arterial stiffness as measured by baPWV and CAVI. CAVI correlated with the Brinkman index, which suggests that CAVI is a useful index of the degree of arterial stiffness caused by smoking.
肱踝脉搏波速度（baPWV）和心踝血管指数（CAVI）用于评估动脉弹性。本研究旨在阐明吸烟对动脉僵硬度的急性和慢性影响，这些影响通过 baPWV 和 CAVI 进行测量。
研究了 10 名男性吸烟者，以评估吸烟对动脉僵硬度的急性影响。为了阐明吸烟对动脉僵硬度的慢性影响，分析了 160 名男性主动吸烟者。CAVI 和 baPWV 通过测量脉搏容积记录、血压（BP）和从心脏到脚踝的血管长度来计算。CAVI 和 baPWV 使用 VaSera VS-1000 进行测量。在急性研究中，吸烟 1 支烟后，baPWV 和 CAVI 立即增加。在慢性研究中，baPWV 和 CAVI 与平均 BP（MBP）和 Brinckman 指数显著相关。在多元回归分析中，baPWV 与 MBP 独立相关，CAVI 与 Brinckman 指数独立相关，但与 MBP 无关。baPWV 和 CAVI 预测 Brinckman 指数≥500 的受试者工作特征（ROC）曲线表明，CAVI 的 ROC 曲线下面积高于 baPWV。
吸烟导致 baPWV 和 CAVI 测量的动脉僵硬度显著增加。CAVI 与 Brinckman 指数相关，提示 CAVI 是评估吸烟引起的动脉僵硬度程度的有用指标。
