Gruzdeva Olga, Borodkina Daria, Uchasova Evgenya, Dyleva Yulia, Barbarash Olga
Federal State Budgetary Institution, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation,
Federal State Budget Educational Institution of Higher Education, Kemerovo State Medical University of the Ministry of Healthcare of the Russian Federation, Kemerovo, Russian Federation.
Diabetes Metab Syndr Obes. 2019 Jan 25;12:191-198. doi: 10.2147/DMSO.S182406. eCollection 2019.
Leptin and its receptors have been identified as key regulators of body weight and energy homeostasis. A decrease in tissue sensitivity to leptin leads to the development of obesity and metabolic disorders, such as insulin resistance and dyslipidemia. Mechanisms underlying the development of leptin resistance include mutations in the genes encoding leptin and its receptors, as well as proteins involved in self-regulation of leptin synthesis and blood-brain barrier permeability. Leptin resistance encompasses a complex pathophysiological phenomenon with a number of potential research lines. In this review, we analyze the existing data on the methods used to diagnose leptin resistance.
瘦素及其受体已被确定为体重和能量稳态的关键调节因子。组织对瘦素的敏感性降低会导致肥胖和代谢紊乱的发生，如胰岛素抵抗和血脂异常。瘦素抵抗发生的机制包括编码瘦素及其受体的基因突变，以及参与瘦素合成自我调节和血脑屏障通透性的蛋白质。瘦素抵抗是一种具有多种潜在研究方向的复杂病理生理现象。在本综述中，我们分析了用于诊断瘦素抵抗的方法的现有数据。
