Cheng Murong, Meng Yuchi, Song Zhenxue, Zhang Ling, Zeng Yuanjun, Zhang Dongfeng, Li Suyun
Department of Epidemiology and Health Statistics, School of Public Health, Qingdao University, Qingdao 266071, China.
Nutrients. 2025 Jan 10;17(2):236. doi: 10.3390/nu17020236.
Although several studies have demonstrated a link between obesity and cognitive function, the majority have primarily utilized body mass index (BMI) and waist circumference, ignoring the distribution of body fat. Evidence regarding the association of metabolic score for visceral fat (METS-VF), a proposed measurement for visceral adipose tissue (VAT), with cognitive function remains limited. We mainly aimed to investigate this association in older adults in the United States.
Data were from the National Health and Nutrition Examination Survey (NHANES) 2011 to 2014. Weighted linear regression models were adopted to examine the association of METS-VF and cognitive function scores, with further exploration of these associations across different obesity subgroups. Smoothing curve analysis, along with threshold and saturation effect analysis, were conducted to explore potential non-linear relationships.
In the multivariable-adjusted model, participants in the highest quartile (Quartile 4) of METS-VF exhibited a β coefficient of -1.52 [95% CI (-2.43, -0.62)] for the CERAD score compared with those in the lowest quartile (Quartile 1). Threshold and saturation effect analysis revealed non-linear associations of METS-VF with DSST score and Z-score.
The findings of this study indicate that elevated METS-VF scores are inversely related to cognitive function, highlighting the importance of considering visceral fat distribution in cognitive health assessments.
尽管多项研究已证明肥胖与认知功能之间存在联系，但大多数研究主要使用体重指数（BMI）和腰围，而忽略了身体脂肪的分布。关于内脏脂肪代谢评分（METS-VF，一种用于测量内脏脂肪组织（VAT）的指标）与认知功能之间关联的证据仍然有限。我们主要旨在调查美国老年人中的这种关联。
数据来自2011年至2014年的美国国家健康与营养检查调查（NHANES）。采用加权线性回归模型来检验METS-VF与认知功能评分之间的关联，并进一步探索这些关联在不同肥胖亚组中的情况。进行了平滑曲线分析以及阈值和饱和效应分析，以探索潜在的非线性关系。
在多变量调整模型中，与最低四分位数（四分位数1）的参与者相比，METS-VF最高四分位数（四分位数4）的参与者在CERAD评分上的β系数为-1.52 [95%置信区间（-2.43，-0.62）]。阈值和饱和效应分析揭示了METS-VF与DSST评分和Z评分之间的非线性关联。
本研究结果表明，升高的METS-VF评分与认知功能呈负相关，突出了在认知健康评估中考虑内脏脂肪分布的重要性。
