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Clin Cancer Res. 2017 Apr 15;23(8):2027-2037. doi: 10.1158/1078-0432.CCR-16-0453. Epub 2016 Sep 27.

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Advances in targeted therapy and biomarker research in thyroid cancer.甲状腺癌的靶向治疗和生物标志物研究进展。
Front Endocrinol (Lausanne). 2024 Mar 4;15:1372553. doi: 10.3389/fendo.2024.1372553. eCollection 2024.
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Combination Inhibition with the Multitargeting Tyrosine Kinase Inhibitor Axitinib Shows Additive Anticancer Activity in -Mutant Anaplastic Thyroid Cancer.联合使用多靶点酪氨酸激酶抑制剂阿昔替尼可增强 - 突变型甲状腺未分化癌的抗癌活性。
Thyroid. 2023 Oct;33(10):1201-1214. doi: 10.1089/thy.2023.0201. Epub 2023 Oct 3.
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Bromodomain 4 inhibition leads to MYCN downregulation in Wilms tumor.溴结构域蛋白 4 抑制导致肾母细胞瘤中 MYCN 的下调。
Pediatr Blood Cancer. 2022 Feb;69(2):e29401. doi: 10.1002/pbc.29401. Epub 2021 Oct 24.

本文引用的文献

1
Synergistic effects of BET and MEK inhibitors promote regression of anaplastic thyroid tumors.BET和MEK抑制剂的协同作用促进间变性甲状腺肿瘤消退。
Oncotarget. 2018 Oct 23;9(83):35408-35421. doi: 10.18632/oncotarget.26253.
2
Genetic Analysis of 779 Advanced Differentiated and Anaplastic Thyroid Cancers.779 例高级别分化型和间变性甲状腺癌的遗传学分析。
Clin Cancer Res. 2018 Jul 1;24(13):3059-3068. doi: 10.1158/1078-0432.CCR-18-0373. Epub 2018 Apr 3.
3
Vemurafenib-resistance via de novo RBM genes mutations and chromosome 5 aberrations is overcome by combined therapy with palbociclib in thyroid carcinoma with BRAF.在具有BRAF的甲状腺癌中,通过与帕博西尼联合治疗可克服因从头RBM基因突变和5号染色体畸变导致的维莫非尼耐药。
Oncotarget. 2017 Sep 24;8(49):84743-84760. doi: 10.18632/oncotarget.21262. eCollection 2017 Oct 17.
4
Dabrafenib and Trametinib Treatment in Patients With Locally Advanced or Metastatic BRAF V600-Mutant Anaplastic Thyroid Cancer.达拉非尼联合曲美替尼治疗局部晚期或转移性 BRAF V600 突变型甲状腺癌患者。
J Clin Oncol. 2018 Jan 1;36(1):7-13. doi: 10.1200/JCO.2017.73.6785. Epub 2017 Oct 26.
5
Targeting MYC as a Therapeutic Intervention for Anaplastic Thyroid Cancer.靶向MYC作为间变性甲状腺癌的一种治疗干预措施。
J Clin Endocrinol Metab. 2017 Jul 1;102(7):2268-2280. doi: 10.1210/jc.2016-3771.
6
Design and characterization of bivalent BET inhibitors.二价溴结构域和额外末端结构域(BET)抑制剂的设计与表征
Nat Chem Biol. 2016 Dec;12(12):1089-1096. doi: 10.1038/nchembio.2209. Epub 2016 Oct 24.
7
Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers.低分化和间变性甲状腺癌的基因组和转录组特征
J Clin Invest. 2016 Mar 1;126(3):1052-66. doi: 10.1172/JCI85271. Epub 2016 Feb 15.
8
The Bromodomain: A New Target in Emerging Epigenetic Medicine.溴结构域:新兴表观遗传学药物的新靶点。
ACS Chem Biol. 2016 Mar 18;11(3):598-608. doi: 10.1021/acschembio.5b00831. Epub 2015 Dec 3.
9
BET bromodomain inhibition as a therapeutic strategy to target c-Myc.BET 溴结构域抑制作为靶向 c-Myc 的治疗策略。
Cell. 2011 Sep 16;146(6):904-17. doi: 10.1016/j.cell.2011.08.017. Epub 2011 Sep 1.

A novel combined targeted therapy with bromodomain antagonist and MEK inhibitor in anaplastic thyroid cancer.

作者信息

Nucera Carmelo

机构信息

Carmelo Nucera: Human Thyroid Cancers Preclinical and Translational Research Program, Harvard Medical School, Boston, MA, USA.

出版信息

Oncotarget. 2019 Jan 22;10(7):686-687. doi: 10.18632/oncotarget.26591.

DOI:10.18632/oncotarget.26591
PMID:30774767
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6366830/
Abstract
摘要