School of Nursing, Nanjing University of Chinese Medicine, Nanjing, China.
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Front Endocrinol (Lausanne). 2024 Mar 4;15:1372553. doi: 10.3389/fendo.2024.1372553. eCollection 2024.
Driven by the intricacy of the illness and the need for individualized treatments, targeted therapy and biomarker research in thyroid cancer represent an important frontier in oncology. The variety of genetic changes associated with thyroid cancer demand more investigation to elucidate molecular details. This research is clinically significant since it can be used to develop customized treatment plans. A more focused approach is provided by targeted therapies, which target certain molecular targets such as mutant BRAF or RET proteins. This strategy minimizes collateral harm to healthy tissues and may also reduce adverse effects. Simultaneously, patient categorization based on molecular profiles is made possible by biomarker exploration, which allows for customized therapy regimens and maximizes therapeutic results. The benefits of targeted therapy and biomarker research go beyond their immediate clinical impact to encompass the whole cancer landscape. Comprehending the genetic underpinnings of thyroid cancer facilitates the creation of novel treatments that specifically target aberrant molecules. This advances the treatment of thyroid cancer and advances precision medicine, paving the way for the treatment of other cancers. Taken simply, more study on thyroid cancer is promising for better patient care. The concepts discovered during this investigation have the potential to completely transform the way that care is provided, bringing in a new era of personalized, precision medicine. This paradigm shift could improve the prognosis and quality of life for individuals with thyroid cancer and act as an inspiration for advances in other cancer types.
受疾病复杂性和个体化治疗需求的驱动,甲状腺癌的靶向治疗和生物标志物研究代表了肿瘤学的一个重要前沿领域。与甲状腺癌相关的各种遗传变化需要更多的研究来阐明分子细节。这项研究具有重要的临床意义,因为它可以用于制定定制的治疗计划。靶向治疗提供了更有针对性的方法,靶向某些分子靶点,如突变的 BRAF 或 RET 蛋白。这种策略最大限度地减少了对健康组织的附带损害,也可能减少不良反应。同时,通过生物标志物探索,根据分子谱对患者进行分类,从而实现了定制化的治疗方案,并最大限度地提高了治疗效果。靶向治疗和生物标志物研究的好处不仅限于其直接的临床影响,还涵盖了整个癌症领域。理解甲状腺癌的遗传基础有助于开发专门针对异常分子的新型治疗方法。这推进了甲状腺癌的治疗,推进了精准医学,为治疗其他癌症铺平了道路。简单地说,对甲状腺癌的更多研究有望为患者提供更好的护理。在这项研究中发现的概念有可能彻底改变护理方式,开创个性化、精准医学的新时代。这种范式转变可以改善甲状腺癌患者的预后和生活质量,并为其他癌症类型的进展提供灵感。