Rahman Adeyemi, O'Sullivan Patrick, Rozas Isabel
School of Chemistry , Trinity Biomedical Sciences Institute , Trinity College Dublin , 152-160-Pearse Street , Dublin 2 , Ireland . Email:
Medchemcomm. 2018 Dec 12;10(1):26-40. doi: 10.1039/c8md00425k. eCollection 2019 Jan 1.
The macromolecule that carries genetic information, DNA, is considered as an exceptional target for diseases depending on cellular division of malignant cells ( cancer), microbes ( bacteria) or parasites ( protozoa). To aim for a comprehensive review to cover all aspects related to DNA targeting would be an impossible task and, hence, the objective of the present review is to present, from a medicinal chemistry point of view, recent developments of compounds targeting the minor groove of DNA. Accordingly, we discuss the medicinal chemistry aspects of heterocyclic small-molecules binding the DNA minor groove, as novel anticancer, antibacterial and antiparasitic agents.
携带遗传信息的大分子DNA，被视为针对依赖恶性细胞（癌症）、微生物（细菌）或寄生虫（原生动物）细胞分裂的疾病的一个特殊靶点。旨在全面涵盖与DNA靶向相关的所有方面进行综述将是一项不可能完成的任务，因此，本综述的目的是从药物化学的角度介绍靶向DNA小沟的化合物的最新进展。相应地，我们将讨论作为新型抗癌、抗菌和抗寄生虫药物的结合DNA小沟的杂环小分子的药物化学方面。
