Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, UK.
Medicines Monitoring Unit (MEMO), Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK.
Nature. 2018 Jul;559(7715):498-506. doi: 10.1038/s41586-018-0327-4. Epub 2018 Jul 25.
Infectious tropical diseases have a huge effect in terms of mortality and morbidity, and impose a heavy economic burden on affected countries. These diseases predominantly affect the world's poorest people. Currently available drugs are inadequate for the majority of these diseases, and there is an urgent need for new treatments. This Review discusses some of the challenges involved in developing new drugs to treat these diseases and highlights recent progress. While there have been notable successes, there is still a long way to go.
传染性热带病在死亡率和发病率方面有重大影响，给受影响国家带来沉重的经济负担。这些疾病主要影响世界上最贫困的人群。目前现有的药物不足以治疗大多数这些疾病，因此急需新的治疗方法。本综述讨论了开发新药治疗这些疾病所面临的一些挑战，并强调了最近的进展。虽然已经取得了显著的成功，但仍有很长的路要走。
