Rosengren Helena, Heal Clare F, Buettner Petra G
School of Medicine, James Cook University, Townsville, Queensland, Australia; Skin Cancer College of Australasia, Brisbane, Queensland, Australia; Skin Repair Skin Cancer Clinic, Townsville, Queensland, Australia.
School of Medicine, James Cook University, Mackay, Queensland, Australia.
Dermatol Pract Concept. 2019 Jan 31;9(1):28-35. doi: 10.5826/dpc.0901a08. eCollection 2019 Jan.
Surgical site infection (SSI) rates for below-knee dermatological surgery are unacceptably high, particularly following complex flap and graft closures. The role of antibiotic prophylaxis for these surgical cases is uncertain.
To determine whether SSI following complex dermatological closures on the leg could be reduced by antibiotic prophylaxis administered as a single oral preoperative dose.
A total of 115 participants were randomized to 2 g of oral cephalexin or placebo 40-60 minutes prior to surgical incision in a prospective, randomized, double-blind, placebo-controlled trial at a primary care skin cancer clinic in North Queensland, Australia.
Overall 17/55 (30.9%) controls and 14/55 (25.5%) intervention participants developed infection (P = 0.525). There was no difference between the study groups in adverse symptoms that could be attributed to high-dose antibiotic administration (P = 1).
A single oral 2-g dose of cephalexin given before complex below-knee dermatological closure did not reduce SSI.
膝下皮肤科手术的手术部位感染（SSI）发生率高得令人无法接受，尤其是在复杂皮瓣和植皮闭合术后。抗生素预防在这些手术病例中的作用尚不确定。
确定术前单次口服抗生素预防能否降低腿部复杂皮肤科闭合术后的SSI。
在澳大利亚北昆士兰的一家初级保健皮肤癌诊所进行的一项前瞻性、随机、双盲、安慰剂对照试验中，共有115名参与者在手术切口前40 - 60分钟被随机分配接受2克口服头孢氨苄或安慰剂。
总体而言，17/55（30.9%）的对照组和14/55（25.5%）的干预组参与者发生了感染（P = 0.525）。在可归因于高剂量抗生素给药的不良症状方面，研究组之间没有差异（P = 1）。
在膝下复杂皮肤科闭合术前单次口服2克头孢氨苄并不能降低SSI。
