Cadavid Ana Maria Hoyos, Teshima Tathyane Harumi Nakajima, Pinto Clóvis Antônio Lopes, Camillo Cláudia Malheiros Coutinho, Lourenço Silvia Vanessa
Universidade de São Paulo (USP), School of Dentistry, Department of Stomatology. São Paulo, SP, Brazil.
AC Camargo Cancer Center, Department of Pathology. São Paulo, SP, Brazil.
Autops Case Rep. 2018 Oct 9;8(4):e2018052. doi: 10.4322/acr.2018.052. eCollection 2018 Oct-Dec.
Ameloblastoma with granular cell pattern (AGC) is classified as an unusual histological subtype of solid/multicystic ameloblastoma, characterized by granular changes in stellate-like cells located within the inner portion of the epithelial follicles. Studies have revealed that lysosomal overload causes cytoplasmic granularity; however, the mechanism involved remains poorly understood. Here we report on eight cases of granular cell ameloblastoma, in the posterior region of the mandible. The age of the patients included in this case series ranged from 35 -64 years old and 87.5% of cases occurred in non-Caucasians, with a slight gender predilection for men (62.5%). There was no evidence of recurrence, and the majority of the cases were treated with surgical resection (87.5%). All tumors displayed histopathological features consistent with the diagnosis of ameloblastoma with granular cell pattern.
颗粒细胞型成釉细胞瘤（AGC）被归类为实性/多囊性成釉细胞瘤的一种罕见组织学亚型，其特征是上皮滤泡内部的星状样细胞出现颗粒变化。研究表明，溶酶体过载会导致细胞质颗粒化；然而，其中涉及的机制仍知之甚少。在此，我们报告8例发生在下颌骨后部的颗粒细胞型成釉细胞瘤病例。该病例系列中的患者年龄在35至64岁之间，87.
