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血清素再摄取抑制剂与骨骼健康：临床研究及可能机制综述

Serotonin reuptake inhibitors and bone health: A review of clinical studies and plausible mechanisms.

作者信息

Wadhwa Ravisha, Kumar Manoj, Talegaonkar Sushama, Vohora Divya

机构信息

Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.

Pharmaceutical Medicine, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.

出版信息

Osteoporos Sarcopenia. 2017 Jun;3(2):75-81. doi: 10.1016/j.afos.2017.05.002. Epub 2017 Jun 9.

DOI:10.1016/j.afos.2017.05.002
PMID:30775508
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6372777/
Abstract

Selective serotonin reuptake inhibitors (SSRIs) are currently the treatment of choice in depression and constitute major portion of prescription in depressive patients. The role of serotonin receptors in bone is emerging, raising certain questions regarding the effect of blockade of serotonin reuptake in the bone metabolism. Clinical studies have reported an association of SSRI antidepressants which with increase in fracture and decrease in bone mineral density. This review focus on recent evidence that evaluate the association of SSRIs with the risk of fracture and bone mineral density and also the probable mechanisms that might be involved in such effects.

摘要

选择性5-羟色胺再摄取抑制剂（SSRIs）目前是治疗抑郁症的首选药物，并且在抑郁症患者的处方中占很大比例。5-羟色胺受体在骨骼中的作用正在显现，这引发了一些关于阻断5-羟色胺再摄取对骨代谢影响的问题。临床研究报告称，SSRI类抗抑郁药与骨折增加和骨矿物质密度降低有关。这篇综述聚焦于近期的证据，这些证据评估了SSRIs与骨折风险和骨矿物质密度之间的关联，以及可能与此类效应相关的潜在机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e627/6372777/c74949685ef5/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e627/6372777/24e54b7fe0ed/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e627/6372777/c74949685ef5/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e627/6372777/24e54b7fe0ed/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e627/6372777/c74949685ef5/gr2.jpg

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Serotonin-reuptake inhibitors act centrally to cause bone loss in mice by counteracting a local anti-resorptive effect.血清素再摄取抑制剂通过抵消局部抗吸收作用在小鼠体内产生中枢性骨质流失。
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