Imga Narin Nasiroglu, Berker Dilek, Can Bulent, Guler Serdar
Department of Endocrinology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
Arch Med Sci Atheroscler Dis. 2018 Mar 27;3:e60-e67. doi: 10.5114/amsad.2018.74784. eCollection 2018.
Vitamin D deficiency is a common health problem worldwide and tends to be a risk factor for all-cause mortality. We evaluated the effect of continuous low-dose oral daily and loading dose of oral weekly and loading monthly intramuscular (IM) vitamin D regimens on circulating levels of total 25(OH)D and in vitamin D deficient females, and between non-obese and obese subgroups.
A total of 231 vitamin D deficient females were included to the study. According to treatment regimen, patients were divided into three groups: daily continuous oral, loading dose of weekly oral and monthly intramuscular. All patients in treatment groups were divided into non-obese (105) and obese (126) groups. Serum 25(OH)D and parathormone (PTH) levels were evaluated at baseline and at the third and sixth month.
In obese patients oral weekly loading regimen and in non-obese patients oral daily continuous regimens were found to be more potent. Baseline PTH levels decreased when compared with the third and sixth months ( < 0.001), but between the third and sixth months it was not changed ( = 0.783).
Oral daily regimen in non-obese patients and loading weekly oral regimen in obese patients were more effective in achieving the target levels of 25(OH)D concentration above 30 ng/ml and provided a stable plasma vitamin D concentration over a long period of time.
维生素D缺乏是全球常见的健康问题，往往是全因死亡率的一个风险因素。我们评估了每日持续低剂量口服、每周口服负荷剂量以及每月肌肉注射（IM）负荷剂量维生素D方案对维生素D缺乏女性循环中总25(OH)D水平的影响，以及在非肥胖和肥胖亚组之间的影响。
共有231名维生素D缺乏女性纳入本研究。根据治疗方案，患者分为三组：每日持续口服组、每周口服负荷剂量组和每月肌肉注射组。治疗组的所有患者又分为非肥胖组（105例）和肥胖组（126例）。在基线、第三个月和第六个月评估血清25(OH)D和甲状旁腺激素（PTH）水平。
发现肥胖患者采用每周口服负荷方案，非肥胖患者采用每日持续口服方案效果更佳。与第三个月和第六个月相比，基线PTH水平降低（<0.001），但在第三个月和第六个月之间未发生变化（=0.783）。
非肥胖患者采用每日口服方案，肥胖患者采用每周口服负荷方案，在使25(OH)D浓度达到高于30 ng/ml的目标水平方面更有效，并能在较长时间内提供稳定的血浆维生素D浓度。
