水合离子液体能够同时溶解和复性聚集的伴刀豆球蛋白 A。
Hydrated ionic liquids enable both solubilisation and refolding of aggregated concanavalin A.
机构信息
Department of Pathophysiology, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan.
出版信息
Chem Commun (Camb). 2019 Mar 21;55(25):3578-3581. doi: 10.1039/c8cc10102g.
PMID:30775731
Abstract
The dissolution and refolding of aggregated concanavalin A have been achieved, in hydrated ionic liquids containing a limited number of water molecules. Both ammonium and phosphonium salts were examined to find a suitable hydrophobicity of ions and water content for refolding. Recovery of sugar recognition was confirmed as a proof of refolding.
摘要
在含有少量水分子的水合离子液体中，实现了聚集的伴刀豆球蛋白 A 的溶解和重折叠。研究了铵盐和鏻盐，以找到适合重折叠的离子疏水性和含水量。糖识别的恢复被确认为重折叠的证明。
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