Department of Psychological and Brain Sciences, Washington University, St. Louis, Missouri, USA.
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.
Mov Disord. 2019 Feb;34(2):285-291. doi: 10.1002/mds.27575. Epub 2018 Dec 10.
Clinicians and researchers commonly use global cognitive assessments to screen for impairment. Currently there are no published studies directly comparing the sensitivity and specificity of the Montreal Cognitive Assessment and Mattis Dementia Rating Scale-2 in PD. The objective of this study was to identify the relative sensitivity and specificity of the Montreal Cognitive Assessment and Mattis Dementia Rating Scale-2 in PD.
The Montreal Cognitive Assessment and Mattis Dementia Rating Scale-2 were administered to training and validation cohorts. Cutoff scores were determined within the training cohort (n = 85) to optimize sensitivity and specificity for cognitive impairment and were applied to an independent validation cohort (n = 521).
The Montreal Cognitive Assessment was consistently sensitive across training and validation cohorts (90.0% and 80.3%, respectively), whereas the Mattis Dementia Rating Scale-2 was not (87.5% and 60.3%, respectively). In individual domains, the Montreal Cognitive Assessment remained sensitive to memory and visuospatial impairments (91.9% and 87.8%, respectively), whereas the Mattis Dementia Rating Scale-2 was sensitive to executive impairments (86.2%).
The Montreal Cognitive Assessment and Mattis Dementia Rating Scale-2 demonstrated individual strengths. Future work should focus on developing domain-specific cognitive screening tools for PD. © 2018 International Parkinson and Movement Disorder Society.
临床医生和研究人员通常使用全球认知评估来筛选损伤。目前尚无研究直接比较蒙特利尔认知评估和 Mattis 痴呆评定量表-2 在 PD 中的敏感性和特异性。本研究旨在确定蒙特利尔认知评估和 Mattis 痴呆评定量表-2 在 PD 中的相对敏感性和特异性。
在训练和验证队列中进行蒙特利尔认知评估和 Mattis 痴呆评定量表-2。在训练队列（n=85）中确定最佳敏感性和特异性的认知障碍的截断值，并将其应用于独立验证队列（n=521）。
蒙特利尔认知评估在训练和验证队列中始终具有较高的敏感性（分别为 90.0%和 80.3%），而 Mattis 痴呆评定量表-2 的敏感性较低（分别为 87.5%和 60.3%）。在个别领域，蒙特利尔认知评估对记忆和视觉空间损伤仍然敏感（分别为 91.9%和 87.8%），而 Mattis 痴呆评定量表-2 对执行功能损伤敏感（86.2%）。
蒙特利尔认知评估和 Mattis 痴呆评定量表-2 各有优势。未来的工作应集中于为 PD 开发特定领域的认知筛查工具。© 2018 国际帕金森病和运动障碍协会。
