Titov V N
National Medical Research Center of Cardiology, Ministry of Health, 121552, Moscow, Russia.
Klin Lab Diagn. 2018;63(11):668-676. doi: 10.18821/0869-2084-2018-63-11-668-676.
For the biological functions of trophology (nutrition) and homeostasis, we believe that the third place is occupied by the function of endoecology: in a single pool of intercellular environment in vivo it must be "pure". The biological function of endoecology, realizes two biological reactions: the reaction of excretion and the reaction of inflammation. The biological reaction of excretion is the filtration of phlogogens of a small mol. mass through the basement membrane of the glomerulus of the nephron and excretion with the final urine. Flogogens are a great mol. mass (more than 70 kDa), catabolites of biological reactions of apoptosis, autophagy must be disposed of in situ, on site. At the stages of phylogenesis, the cells formed structures for the collection and utilization of phlogogens of large mol. mass and exogenous pathogens in tissues. The sequence of biochemical reactions, biological methods of in vivo collection and in situ utilization of phlogogens of large mol. mass and realizes the biological function of endoecology, the biological reaction of inflammation. It functions constantly, every minute, like the biological reaction of excretion. Inflammation is the reaction of maintaining the "cleanliness" of the "piece" of the ocean that every individual has privatized, before beginning to live on land. The inflammation reaction includes congenital, acquired immunity, humoral mediator systems, cytokines and eicosanoids. In the formation of a closed circulatory system, the pool for collecting and utilizing in situ biological catabolites from the bloodstream is located in the late phylogeny of the intima of the arteries of the elastic (muscular-elastic) type. Abuse of herbivorous species Homo sapiens carnivorous (meat) food; blockade of cellular absorption by polyene fatty acids in low density lipoproteins and the absence of acidic hydrolase expression of polyene fatty acids - cholesterol alcohol ethers in monocytes and macrophages - is the cause of the formation of atheroma of intima of the arteries of the elastic type. Atherosclerosis - the pathology of the biological function of trophology, atheromatosis - pathology of the biological function of endoecology. The appointment of patients statins for primary prevention of atherosclerosis, atheromatosis and coronary heart disease, we finally "passed".
对于营养（营养生理学）和内环境稳定的生物学功能，我们认为第三位由内生态学功能占据：在体内单一的细胞间环境池中，它必须是“纯净的”。内生态学的生物学功能实现了两种生物学反应：排泄反应和炎症反应。排泄的生物学反应是小分子致炎物质通过肾单位肾小球的基底膜过滤并随终尿排出。致炎物质是大分子物质（超过70 kDa），凋亡、自噬生物学反应的分解代谢产物必须在原位、就地处理。在系统发育阶段，细胞形成了在组织中收集和利用大分子致炎物质及外源病原体的结构。大分子致炎物质在体内收集和原位利用的生化反应序列及生物学方法实现了内生态学的生物学功能，即炎症生物学反应。它像排泄生物学反应一样每分钟都在持续发挥作用。炎症是在个体开始在陆地上生活之前，维持每个个体“私有化”的那片“海洋区域”“清洁”的反应。炎症反应包括先天性、获得性免疫、体液介质系统、细胞因子和类二十烷酸。在封闭循环系统形成过程中，从血液中收集和原位利用生物分解代谢产物的池位于弹性（肌弹性）型动脉内膜的系统发育后期。人类这种草食性物种对肉食的滥用；低密度脂蛋白中多烯脂肪酸对细胞吸收的阻断以及单核细胞和巨噬细胞中多烯脂肪酸 - 胆固醇醇醚酸性水解酶表达的缺失 - 是弹性型动脉内膜动脉粥样硬化形成的原因。动脉粥样硬化 - 营养生理学生物学功能的病理学，动脉粥样瘤 - 内生态学生物学功能的病理学。我们最终“认可”了给患者使用他汀类药物进行动脉粥样硬化、动脉粥样瘤和冠心病一级预防的做法。
