National Cancer Control Institute, National Cancer Center, Goyang, Korea.
Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea.
Cancer Res Treat. 2019 Oct;51(4):1285-1294. doi: 10.4143/crt.2018.464. Epub 2019 Feb 19.
To reduce lung cancer mortality, lung cancer screening was recommended using low-dose computed tomography (LDCT) to high-risk population. A protocol for multicenter lung cancer screening pilot project was developed to evaluate the effectiveness and feasibility of lung cancer screening to implement National Cancer Screening Program in Korea.
Multidisciplinary expert committee was comprised to develop a standardized protocol for Korean Lung Cancer Screening Project (K-LUCAS). K-LUCAS is a population-based single arm trial that targets high-risk population aged 55-74 years with at least 30 pack-year smoking history. LDCT results are reported by Lung-RADS suggested by American Radiology Society. Network-based system using computer-aided detection program is prepared to assist reducing diagnostic errors. Smoking cessation counselling is provided to all currently smoking participants. A small pilot test was conducted to check the feasibility and compliance of the protocols for K-LUCAS.
In pilot test, 256 were participated. The average age of participants was 63.2 years and only three participants (1.2%) were female. The participants had a smoking history of 40.5 pack-year on average and 53.9% were current smokers. Among them, 86.3% had willing to participate in lung cancer screening again. The average willingness to quit smoking among current smokers was 12.7% higher than before screening. In Lung-RADS reports, 10 (3.9%) were grade 3 and nine (3.5%) were grade 4. One participant was diagnosed as lung cancer.
The protocol developed by this study is assessed to be feasible to perform K-LUCAS in multicenter nationwide scale.
为降低肺癌死亡率，推荐使用低剂量计算机断层扫描（LDCT）对高危人群进行肺癌筛查。制定了一项多中心肺癌筛查试点项目方案，以评估在韩国实施国家癌症筛查计划的肺癌筛查的有效性和可行性。
成立了多学科专家委员会，制定了韩国肺癌筛查项目（K-LUCAS）的标准化方案。K-LUCAS 是一项基于人群的单臂试验，目标人群为年龄在 55-74 岁、有至少 30 包年吸烟史的高危人群。LDCT 结果按照美国放射学会提出的 Lung-RADS 进行报告。准备了基于网络的系统，使用计算机辅助检测程序，以协助减少诊断错误。为所有目前吸烟的参与者提供戒烟咨询。进行了小规模的试点测试，以检查 K-LUCAS 方案的可行性和依从性。
在试点测试中，有 256 人参加。参与者的平均年龄为 63.2 岁，只有 3 名参与者（1.2%）为女性。参与者的吸烟史平均为 40.5 包年，53.9%为当前吸烟者。其中，86.3%的人愿意再次参加肺癌筛查。当前吸烟者的平均戒烟意愿比筛查前提高了 12.7%。在 Lung-RADS 报告中，有 10 人（3.9%）为 3 级，9 人（3.5%）为 4 级。有 1 名参与者被诊断为肺癌。
本研究制定的方案被评估为在多中心全国范围内开展 K-LUCAS 是可行的。
