Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Immunobiology. 2019 May;224(3):402-407. doi: 10.1016/j.imbio.2019.02.007. Epub 2019 Feb 12.
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system. Nearly 85% of MS patients are recognized with relapsing-remitting MS (RRMS), a typical clinical course of disease which is distinguished by several episodes of relapses, separated by remissions of neurological impairment. Failure of repair mechanisms is a main factor in progression of neurological dysfunction in MS. Several lines of evidence suggest that Reelin (RELN) signaling pathway can contribute in the regulation of repair mechanisms in MS patients. In the present study, we assessed expression levels of RELN and Disabled-1 (DAB1), two key genes in RELN signaling pathway, in peripheral blood of 50 RRMS patients and 50 matched healthy subjects. RELN was significantly down-regulated in total MS patients, and total female patients compared with the matched controls. However, no statistically significant difference was found in DAB1 mRNA expression between MS patients and controls. Furthermore, considerable correlations were detected between expression levels of RELN and DAB1 in the patients group. There were no significant correlations between expression levels of genes and EDSS, disease duration or age at onset. Our study provides evidences for the role of RELN signaling pathway in the pathogenesis of MS. Further studies are required to clarify the exact clinical significance of this pathway in MS patients.
多发性硬化症（MS）是一种中枢神经系统的慢性脱髓鞘疾病。近 85%的 MS 患者被诊断为复发缓解型多发性硬化症（RRMS），这是一种典型的疾病临床过程，其特点是多次复发，伴有神经功能缺损的缓解。修复机制的失败是 MS 患者神经功能障碍进展的主要因素。有几条证据表明，Reelin（RELN）信号通路可以有助于调节 MS 患者的修复机制。在本研究中，我们评估了 50 名 RRMS 患者和 50 名匹配健康受试者外周血中 RELN 和Disabled-1（DAB1）这两个 RELN 信号通路关键基因的表达水平。与匹配对照组相比，总 MS 患者和总女性患者的 RELN 表达显著下调。然而，MS 患者与对照组之间 DAB1mRNA 表达无统计学差异。此外，在患者组中还检测到 RELN 和 DAB1 表达水平之间存在相当大的相关性。基因表达水平与 EDSS、疾病持续时间或发病年龄之间无显著相关性。我们的研究为 RELN 信号通路在 MS 发病机制中的作用提供了证据。需要进一步的研究来阐明该通路在 MS 患者中的确切临床意义。
