Pfizer Vaccines Medical Development & Scientific and Clinical Affairs , Collegeville , PA , USA.
Pfizer Vaccine Clinical Research and Development , Pearl River , NY , USA.
Hum Vaccin Immunother. 2019;15(9):2205-2216. doi: 10.1080/21645515.2019.1581542. Epub 2019 Apr 19.
Invasive meningococcal disease (IMD), a rapidly progressing and potentially fatal illness, disproportionately affects adolescents and young adults. While IMD is best prevented by vaccination, vaccine uptake in these groups is low. An evidence-based understanding of the safety and effectiveness of concomitant vaccination of meningococcal vaccines, including the newer MenB protein vaccines and the more established MenACWY conjugate vaccines, with other vaccines recommended for adolescents and young adults may help maximize vaccination opportunities. We identified 21 studies assessing concomitant administration of meningococcal vaccines with other vaccines in adolescents and adults. Although studies varied in methodology, concomitant administration generally did not affect immunogenicity of the meningococcal or coadministered vaccines. In some cases, reactogenicity increased following concomitant administration, but no definitive safety concerns were raised. In general, data suggest that meningococcal vaccines can be safely and effectively coadministered with other vaccines.
侵袭性脑膜炎球菌病（IMD）是一种迅速发展且可能致命的疾病，青少年和年轻成年人受其影响尤为严重。虽然疫苗接种是预防 IMD 的最佳方法，但这些人群的疫苗接种率却很低。对脑膜炎球菌疫苗（包括新型 MenB 蛋白疫苗和更成熟的 MenACWY 结合疫苗）与其他推荐给青少年和年轻成年人的疫苗同时接种的安全性和有效性的循证理解，可能有助于最大限度地增加疫苗接种机会。我们确定了 21 项研究，评估了脑膜炎球菌疫苗与青少年和成年人的其他疫苗同时接种的情况。尽管研究方法有所不同，但同时接种通常不会影响脑膜炎球菌疫苗或同时接种的疫苗的免疫原性。在某些情况下，同时接种后会增加不良反应，但并未提出明确的安全问题。总的来说，数据表明脑膜炎球菌疫苗可以与其他疫苗安全有效地同时接种。
