Shandong Co-Innovation Center of Classic TCM formula, Shandong University of Traditional Chinese Medicine, Jinan 250355, PR China.
College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, PR China.
Biomed Pharmacother. 2019 Apr;112:108616. doi: 10.1016/j.biopha.2019.108616. Epub 2019 Feb 16.
Depression pertains to the category of "Emotional Diseases" in traditional Chinese medicine (TCM). Its clinical symptoms are similar to the manifestations of "lily disease" from the TCM classics Synopsis of the Golden Chamber written by Zhang Zhongjing in the Han Dynasty. Also in this book, Lily Bulb and Rehmannia Decoction (LBRD) is the formula for the treatment of "lily disease". The classical herbal formula LBRD is composed of two herbs lily bulb and fresh rehmannia juice, with the function of nourishing yin and replenishing heart and lung. It has been clinically applied to treat "lily disease" for two thousand years. In this review, we focused on recent evidence linking LBRD and depression extracting data from animal and clinical studies, summarizing the primitive dosage and producing area of genuine medicinal materials of LBRD, clinical application, pharmacological mechanism and the effective substance basis for the treatment of depression. In conclusion, we discussed existing problems and future perspective. This systematic review will seek to enhance our understanding about pharmacology mechanism, herb-prescribing and recipe-constructing, and the development of novel formula for depression treatments.
抑郁症属于中医“情志病”范畴。其临床表现类似于汉代张仲景所著《金匮要略》中“百合病”的表现。在这本书中，百合地黄汤（LBRD）是治疗“百合病”的方剂。经典的草药配方 LBRD 由百合和鲜地黄汁两种草药组成，具有滋阴润肺的作用。两千年来，它已在临床上用于治疗“百合病”。在这篇综述中，我们重点关注了最近的证据，这些证据将 LBRD 与抑郁症联系起来，从动物和临床研究中提取数据，总结了 LBRD 的原始剂量和地道药材产地、临床应用、药理机制以及治疗抑郁症的有效物质基础。总之，我们讨论了存在的问题和未来的展望。本系统评价旨在增强我们对药理学机制、草药处方和方剂构建以及新型抑郁症治疗配方开发的理解。
