Guttikonda Sreedevi, Ahmadi Sara, Urban Randall J
a Department of Endocrinology and Metabolism, University of Texas Medical Branch, Galveston, TX, USA.
b
Expert Rev Endocrinol Metab. 2011 Sep;6(5):697-703. doi: 10.1586/eem.11.59.
This article highlights the risk of hypopituitarism in survivors of traumatic brain injury (TBI), an underdiagnosed clinical problem. Clinical evidence shows that anterior pituitary dysfunction is common in TBI survivors evaluated at least 6 months after the TBI, with an estimated prevalence of up to 27.5%. Although patients who suffer from moderate-to-severe TBI appear to be at higher risk, the emerging data suggest that mild-intensity trauma can also precede hypopituitarism. Since many of the symptoms of hypopituitarism are similar to those of TBI, it is important for clinicians to be aware of this clinical problem. Moreover, we will address questions such as when to screen and who should be screened, along with a discussion of current management of pituitary dysfunction in patients with TBI.
本文强调了创伤性脑损伤（TBI）幸存者发生垂体功能减退的风险，这是一个诊断不足的临床问题。临床证据表明，在创伤性脑损伤后至少6个月接受评估的TBI幸存者中，垂体前叶功能障碍很常见，估计患病率高达27.5%。虽然中重度TBI患者似乎风险更高，但新出现的数据表明，轻度创伤也可能导致垂体功能减退。由于垂体功能减退的许多症状与TBI的症状相似，临床医生了解这一临床问题很重要。此外，我们将探讨何时进行筛查、谁应该接受筛查等问题，并讨论TBI患者垂体功能障碍的当前管理方法。
