Kim I
Department of Pathology, Korea University Hospital, Seoul.
J Korean Med Sci. 1987 Jun;2(2):103-10. doi: 10.3346/jkms.1987.2.2.103.
Four cases of well differentiated lymphocytic lymphoma with or without plasmacytoid differentiation of the lung are described. Two cases were single and the others were multiple. Histologic pictures of the lesion showed mass with perivascular, interstitial and alveolar extension in three cases and only interstitial and perivascular involvement in one. Histologically three cases were lymphoplasmacytic lymphoma and one was small lymphocytic lymphoma. Dutcher bodies, granulomas and germinal centers were also found in tumors. Immunohistochemical study revealed monoclonal lymphocytic proliferation in all cases in fresh frozen sections and in three in paraffin sections. Treatment is surgical resection. Chemotherapy is used for residual disease after surgery.
本文描述了4例肺高分化淋巴细胞淋巴瘤，其中部分病例伴有浆细胞样分化。2例为单发病灶，其余为多发病灶。病变的组织学表现为：3例可见肿块伴血管周围、间质及肺泡浸润，1例仅见间质及血管周围受累。组织学上，3例为淋巴浆细胞性淋巴瘤，1例为小淋巴细胞淋巴瘤。肿瘤中还发现了杜氏小体、肉芽肿和生发中心。免疫组化研究显示，所有新鲜冰冻切片病例及3例石蜡切片病例均有单克隆淋巴细胞增殖。治疗方法为手术切除。化疗用于术后残留病灶。
