Thomas J O, Beiske K, Hann I, Koo C, Mason D Y
Department of Haematology, John Radcliffe Hospital, Oxford.
J Clin Pathol. 1991 Aug;44(8):632-5. doi: 10.1136/jcp.44.8.632.
An immunohistological study of paraffin wax embedded tissue from three cases of plasmacytoid monocyte neoplasms, using a panel of antibodies which react with fixation resistant leucocyte markers, is reported. This neoplasm was found to have a distinctive antigenic profile, being negative for CD3 and elastase, but positive for CD43 and CD68. This immunological phenotype, coupled with its characteristic morphological features, should facilitate the recognition of this rare neoplasm in routinely processed tissue. Furthermore, the term "plasmacytoid monocyte sarcoma" is proposed to designate it because it is inappropriate to refer to it as a lymphoma. As all cases have been associated with a myeloproliferative disorder (usually an acute or chronic myeloid leukaemia), these tumours probably represent the accumulation in lymphoid tissue of neoplastic cells which have differentiated along the plasmacytoid monocyte pathway.
报告了一项针对三例浆细胞样单核细胞肿瘤石蜡包埋组织的免疫组织学研究，该研究使用了一组与抗固定白细胞标志物反应的抗体。发现这种肿瘤具有独特的抗原谱，CD3和弹性蛋白酶呈阴性，但CD43和CD68呈阳性。这种免疫表型及其特征性形态学特征，应有助于在常规处理的组织中识别这种罕见肿瘤。此外，建议使用“浆细胞样单核细胞肉瘤”这一术语来命名它，因为将其称为淋巴瘤是不合适的。由于所有病例均与骨髓增殖性疾病（通常为急性或慢性髓系白血病）相关，这些肿瘤可能代表了沿浆细胞样单核细胞途径分化的肿瘤细胞在淋巴组织中的积聚。
