Riaz Thoufiqul Alam, Hossain Shahdat, Ferdous Jannatul, Hossain Mohammad, Islam Muhammad Torequl, Chae Han-Jung, Hossain Muhammad Kamal
Department of Pharmacy, University of Science and Technology Chittagong, Foys Lake, Pahartali (Chittagong), Bangladesh.
Department of Pharmacy, Southern University Bangladesh, Mehedibag (Chittagong), Bangladesh.
Ayu. 2018 Apr-Jun;39(2):101-106. doi: 10.4103/ayu.AYU_213_17.
The herb, (CP) Blume (Family-Commelinaceae) is medicinally used by the traditional practitioners in Bangladesh. However, there is a lack of scientific evidence on this medicinal herb.
This study aimed to evaluate the phytochemical and pharmacological activities of CP (ethanol [ECP], chloroform [CCP] and n-hexane [NHCP] of whole-plant extracts).
For this antioxidant, antimicrobial, antidiarrheal and antipyretic activities of crude extracts of CP were conducted by 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging, disc diffusion and serial dilution, castor oil-induced diarrhea and yeast powder-induced pyrexia methods respectively.
The results suggest that all the fractions significantly scavenged DPPH radicals. In the disc diffusion test, the zones of inhibition were observed within the range of 7 mm to 30.67 mm at 500 mg/disc. The highest zones of inhibition were observed by ECP, CCP and NHCP against and respectively. NHCP was found to exert stronger antibacterial effect than the ECP and CCP.
Minimum inhibitory concentrations were detected within the range of 31.25 and 250 μg/ml. Moreover, the crude fractions also showed significant ( < 0.05) antidiarrheal and antipyretic activities in Swiss mice. CP may be a good source of therapeutic components.
草本植物（鸭跖草科）在孟加拉国被传统医生用于医学用途。然而，关于这种草药缺乏科学证据。
本研究旨在评估全草提取物的鸭跖草（乙醇提取物[ECP]、氯仿提取物[CCP]和正己烷提取物[NHCP]）的植物化学和药理活性。
分别通过1,1-二苯基-2-苦基肼（DPPH）清除法、纸片扩散法和系列稀释法、蓖麻油诱导腹泻法和酵母粉诱导发热法对鸭跖草粗提取物进行抗氧化、抗菌、止泻和解热活性研究。
结果表明，所有提取物均能显著清除DPPH自由基。在纸片扩散试验中，500mg/片时抑菌圈范围为7mm至30.67mm。ECP、CCP和NHCP分别对和观察到最高的抑菌圈。发现NHCP比ECP和CCP具有更强的抗菌作用。
最低抑菌浓度在31.25至250μg/ml范围内。此外，粗提取物在瑞士小鼠中也显示出显著的（<0.05）止泻和解热活性。鸭跖草可能是治疗成分的良好来源。
