2010年与2016年冠状动脉搭桥手术患者心血管危险因素比较：伊朗吉兰省的一项单中心研究

Comparison of cardiovascular risk factors among coronary artery bypass graft patients in 2010 and 2016: A single-center study in Guilan province, Iran.

作者信息

Dadkhah-Tirani Heidar, Hasandokht Tolou, Agostoni Piergiuseppe, Salari Arsalan, Shad Bijan, Soltanipour Soheil

机构信息

Assistant Professor, Cardiovascular Diseases Research Center AND Department of Cardiology, School of Medicine, Heshmat Hospital, Guilan University of Medical Sciences, Rasht, Iran.

Professor, Centro Cardiologico Monzino IRCCS AND Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milano, Milano, Italy.

出版信息

ARYA Atheroscler. 2018 Sep;14(5):205-211. doi: 10.22122/arya.v14i5.1740.

DOI:10.22122/arya.v14i5.1740

PMID:30783410

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6368195/

Abstract

BACKGROUND

There has been a change in the risk factor profile of patients with coronary artery disease (CAD) in the western world. We sought to compare the risk factor profile of patients undergoing coronary artery bypass graft (CABG) surgery in northern part of Iran in 2010 and 2016.

METHODS

In a cross-sectional study, medical records of 296 CABG patients in 2010 and 500 patients in 2016 were collected from a referral university hospital in Guilan province, Iran. We compared the risk factor profile using chi-square test or independent t-test as needed in the two time points, 2010 and 2016.

RESULTS

The age of CABG patients significantly decreased from 62.49 ± 8.05 to 58.09 ± 9.20 over time. The frequency of hypertension (HTN) (66.2% vs. 59.1%, P = 0.045), diabetes mellitus (DM) (51.8% vs. 43.6%, P = 0.025), smoking (35.6% vs. 28.0%, P = 0.028), and patients with multimorbidity (31.8% vs. 26.7%, P = 0.001) increased in the second period compared to the first period of study. Whereas, the prevalence of hypercholesterolemia and positive family history of coronary heart disease (CHD) remained stable over time (49.6% vs. 49.0%, P = 0.870; 10.5% vs. 11.1%, P = 0.810, respectively).

CONCLUSION

We observed a dramatic increase in DM, HTN, and cigarette smoking as well as the multimorbidity prevalence in 2016 compared to 2010. Even with considering all study limitations, primary and secondary prevention program to decrease cardiovascular disease is required.

摘要

背景

西方世界冠状动脉疾病（CAD）患者的危险因素状况已发生变化。我们试图比较2010年和2016年伊朗北部接受冠状动脉搭桥术（CABG）的患者的危险因素状况。

方法

在一项横断面研究中，从伊朗吉兰省一家转诊大学医院收集了2010年296例CABG患者和2016年500例患者的病历。我们在2010年和2016年这两个时间点根据需要使用卡方检验或独立t检验比较了危险因素状况。

结果

随着时间的推移，CABG患者的年龄从62.49±8.05显著降至58.09±9.20。与研究的第一阶段相比，第二阶段高血压（HTN）的发生率（66.2%对59.1%，P = 0.045）、糖尿病（DM）（51.8%对43.6%，P = 0.025）、吸烟（35.6%对28.0%，P = 0.028）以及患有多种疾病的患者（31.8%对26.7%，P = 0.001）均有所增加。而高胆固醇血症的患病率和冠心病（CHD）家族史阳性率随时间保持稳定（分别为49.6%对49.0%，P = 0.870；10.5%对11.1%，P = 0.810）。