冠状动脉介入治疗中代谢综合征患者的性别差异。

Gender differences in patients with metabolic syndrome in coronary artery interventions.

作者信息

Rami Helvaci Mehmet, Kaya Hasan, Gundogdu Mehmet

机构信息

1School of Medicine of the Mustafa Kemal University, Antakya, 2School of Medicine of the Ataturk University, Erzurum; Turkey.

出版信息

Med Glas (Zenica). 2013 Feb;10(1):75-80.

PMID:23348166

Abstract

AIM

We tried to understand whether or not there was a gender difference in coronary artery interventions in coronary heart disease (CHD) cases in the present study.

METHODS

The study was performed in two phases. The first phase was performed at the Internal Medicine Polyclinic of the Dumlupinar University between August 2005 and March 2007. CHD was diagnosed either angiographically or with history of coronary artery stenting (CAS) and/or coronary artery bypass graft (CABG) surgery. The second phase was performed at the Internal Medicine Polyclinic of the Mustafa Kemal University between March 2007 and April 2012. During the second phase, the CHD patients with CAS and/or CABG surgery were detected and divided into two groups according to the gender.

RESULTS

Mean age and prevalence of CHD were similar in both genders (p>0.05 for both) in the first phase. Smoking was higher in males with CHD, in 30 cases (54.5%) of males versus six (9.6%) cases of females (p < 0.001), as well as chronic obstructive pulmonary disease (COPD), in ten (18.1%) cases of males versus four (6.4%) cases of females (p < 0.05). Although the body mass index (BMI) and white coat hypertension (WCH) were insignificantly higher (p>0.05 for both), low density lipoprotein cholesterol (LDL-C) and triglyceride (TG) were significantly higher in females with CHD (p= 0.008 and p= 0.002, respectively). Hypertension (HT) and diabetes mellitus (DM) were higher in females with CHD, too (p < 0.001 and p < 0.05, respectively). On the other hand, CAS and/or CABG surgery were significantly higher in male CHD cases (21.8% versus 1.6%, p less 0.001). Parallel to the first phase cases, majority of CAS and/or CABG surgery cases were males in the second phase cases too (90.2% versus 9.7%, p less 0.001).

CONCLUSION

As some components of the metabolic syndrome, smoking and COPD were higher in males whereas BMI, WCH, LDL-C, TG, HT and DM were higher in females. Despite similar prevalences of CHD in both sexes, CAS and/or CABG surgery were significantly higher in males probably due to fear of loss of power required for their dominant roles in life and sexuality.

摘要

目的

在本研究中，我们试图了解冠心病（CHD）患者在冠状动脉介入治疗方面是否存在性别差异。

方法

本研究分两个阶段进行。第一阶段于2005年8月至2007年3月在杜姆卢皮纳尔大学内科综合门诊进行。冠心病通过血管造影或有冠状动脉支架置入术（CAS）和/或冠状动脉旁路移植术（CABG）手术史来诊断。第二阶段于2007年3月至2012年4月在穆斯塔法·凯末尔大学内科综合门诊进行。在第二阶段，检测接受CAS和/或CABG手术的冠心病患者，并根据性别分为两组。

结果

在第一阶段，两性的冠心病平均年龄和患病率相似（两者p>0.05）。冠心病男性患者吸烟率更高，男性30例（54.5%），女性6例（9.6%）（p<0.001），慢性阻塞性肺疾病（COPD）也是如此，男性10例（18.1%），女性4例（6.4%）（p<0.05）。虽然体重指数（BMI）和白大衣高血压（WCH）略高（两者p>0.05），但冠心病女性患者的低密度脂蛋白胆固醇（LDL-C）和甘油三酯（TG）显著更高（分别为p=0.008和p=0.002）。冠心病女性患者的高血压（HT）和糖尿病（DM）也更高（分别为p<0.001和p<0.05）。另一方面，冠心病男性患者的CAS和/或CABG手术显著更多（21.8%对1.6%，p<0.001）。与第一阶段病例相似，在第二阶段病例中，大多数接受CAS和/或CABG手术的也是男性（90.2%对9.7%，p<0.001）。