Faghih Habibi Ali, Gerami Hooshang, Banan Rahmatollah, Kazemnezhad Leily Ehsan, Khoshkhat Parsa, Alaie Alamouti Hooman, Nemati Shadman
Rhino-Sinus, Ear, and Skull base Diseases Research Center, Department of Otolaryngology and Head and Neck Surgury, Amiralmomenin Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
International Campus, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Iran J Otorhinolaryngol. 2019 Jan;31(102):19-24.
Chronic rhinosinusitis (CRS) with and without nasal polyposis is a chronic inflammatory disease of the sinuses and nasal mucosa. Recent evidence has indicated a relationship between serum 25-hydroxyl vitamin D (OH-VitD) deficiency and CRS. Regarding this, the present study aimed to compare the serum level of 25-OH-VitD in CRS patients with and without nasal polyposis and control groups.
This study was conducted on 117 adult subjects in three groups of CRS with nasal polyposis (CRSwNP; n=32), CRS without nasal polyposis (CRSsNP; n=35), and healthy controls (n=50). The mean level of serum 25-OH-VitD in the three groups was measured by means of enzyme- linked immunosorbent assay. The data were analyzed using SPSS software (version 18).
Mean serum levels of 25-OH-VitD in CRSwNP, CRSsNP, and control groups were 12.52, 15.54, and 22.04 ng/ml, respectively. There was a significant difference between the case and control groups in terms of 25-OH-VitD level (P=0.0001). However, no significant difference was observed between the CRSwNP and CRSsNP groups in this regard (P=0.464). The women had a VitD deficiency odds ratio (OR) of 2.47, compared with men (OR=2.47, 95% CI=1.04-5.86). The OR of VitD deficiency with aging was obtained as 0.957 (95% CI=0.925-0.989). In this regard, older patients had a lower probability of VitD deficiency, compared to younger patients.
As the findings indicated, serum 25-OH-VitD was significantly lower in CRS patients, compared with that in the non-CRS subjects.
伴或不伴鼻息肉的慢性鼻-鼻窦炎（CRS）是鼻窦和鼻黏膜的一种慢性炎症性疾病。最近有证据表明血清25-羟基维生素D（OH-VitD）缺乏与CRS之间存在关联。关于此，本研究旨在比较伴和不伴鼻息肉的CRS患者与对照组血清25-OH-VitD水平。
本研究对117名成年受试者进行，分为三组：伴鼻息肉的CRS（CRSwNP；n = 32）、不伴鼻息肉的CRS（CRSsNP；n = 35）和健康对照组（n = 50）。采用酶联免疫吸附测定法测量三组血清25-OH-VitD的平均水平。使用SPSS软件（版本18）对数据进行分析。
CRSwNP组、CRSsNP组和对照组血清25-OH-VitD的平均水平分别为12.52、15.54和22.04 ng/ml。病例组和对照组在25-OH-VitD水平方面存在显著差异（P = 0.0001）。然而，在这方面CRSwNP组和CRSsNP组之间未观察到显著差异（P = 0.464）。女性维生素D缺乏的比值比（OR）为2.47，男性为2.47（95%可信区间[CI] = 1.04 - 5.86）。维生素D缺乏与衰老的OR值为0.957（95%CI = 0.925 - 0.989）。在这方面，老年患者维生素D缺乏的概率低于年轻患者。
如研究结果所示，与非CRS受试者相比，CRS患者血清25-OH-VitD显著降低。
