Department of NCDs Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
Department of Epidemiology, School of Public Health, Peking University Health Science Center, Beijing, China.
J Diabetes Investig. 2019 Sep;10(5):1215-1222. doi: 10.1111/jdi.13028. Epub 2019 Mar 12.
AIMS/INTRODUCTION: Evidence has shown that stressful life events are associated with the development of diabetes, yet studies in mainland China are scarce. In the present study, we explored the associations between cumulative and specific stressful life events and the prevalence of diabetes in Chinese adults.
The cross-sectional data were from the China Kadoorie Biobank study, which enrolled approximately 500,000 adults aged 30-79 years from 10 diverse regions of China. Logistic regression models were used to calculate the adjusted odds ratio (OR) and the 95% confidence interval (CI).
Of the 473,607 participants, 25,301 (5.34%) had type 2 diabetes (2.68% clinically-identified and 2.66% screen-detected). Participants who experienced one and two or more stressful life events were 1.10-fold (OR 1.10, 95% CI 1.05-1.16) and 1.33-fold (OR 1.33, 95% CI 1.13-1.57) more likely to have type 2 diabetes. Three categories of work-related events (OR 1.15, 95% CI 1.01-1.31), as well as family-related events (OR 1.11, 95% CI 1.06-1.18) and personal-related events (OR 1.18, 95% CI 1.03-1.36), were associated with an increased likelihood of type 2 diabetes. Regarding the specific life events, the ORs of loss of job or retirement, as well as major conflict within family, death or major illness of other close family member and major injury or traffic accident, were 1.24 (95% CI 1.02-1.52), 1.24 (95% CI 1.08-1.43), 1.13 (95% CI 1.06-1.20) and 1.20 (95% CI 1.01-1.43), respectively.
The present study showed that cumulative and specific stressful life events were significantly associated with an increased prevalence of diabetes.
目的/引言：有证据表明，生活压力事件与糖尿病的发生发展有关，但中国内地的相关研究较少。本研究旨在探讨中国成年人中累积性和特定生活压力事件与糖尿病患病率之间的关系。
本横断面研究数据来自中国慢性病前瞻性研究（CKB），共纳入来自中国 10 个不同地区的近 50 万名 30-79 岁成年人。采用 logistic 回归模型计算调整后的比值比（OR）及其 95%置信区间（CI）。
在 473607 名参与者中，25301 人（5.34%）患有 2 型糖尿病（2.68%为临床诊断，2.66%为筛查诊断）。经历过 1 次和 2 次及以上生活压力事件的参与者患 2 型糖尿病的风险分别增加 1.10 倍（OR 1.10，95%CI 1.05-1.16）和 1.33 倍（OR 1.33，95%CI 1.13-1.57）。3 类与工作相关的事件（OR 1.15，95%CI 1.01-1.31）、家庭相关事件（OR 1.11，95%CI 1.06-1.18）和个人相关事件（OR 1.18，95%CI 1.03-1.36）与 2 型糖尿病的发生风险增加相关。具体来看，失业或退休、家庭重大冲突、其他近亲死亡或重病、重大伤害或交通事故这 4 项生活压力事件的 OR 值分别为 1.24（95%CI 1.02-1.52）、1.24（95%CI 1.08-1.43）、1.13（95%CI 1.06-1.20）和 1.20（95%CI 1.01-1.43）。
本研究表明，累积性和特定生活压力事件与糖尿病患病率显著相关。
