Department of Cardiology, Anhui Provincial Hospital of Anhui Medical University, Hefei, China.
Department of Cardiology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Adv Clin Exp Med. 2019 May;28(5):651-658. doi: 10.17219/acem/91791.
Toll-like receptor 4 (TLR4) plays an important role in the formation of coronary atherosclerotic plaque and the pathogenesis of coronary artery disease (CAD).
The aim of the study was to conduct a meta-analysis assessing the relationship between 2 common genetic variants in the TLR4 gene (rs4986790 and rs4986791) and susceptibility to CAD.
A systematic search of Web of Science, Embase, Scopus, PubMed, and Wanfang Med Online was undertaken. Case-control studies assessing the association of rs4986790 and rs4986791 with CAD risk were included. The odds ratio (OR) and 95% confidence interval (CI) were used as the metric of choice for the evaluation of risk.
The literature search generated 427 studies, of which 14 met the inclusion criteria, for a total of 13,927 participants. Our meta-analysis revealed a significant association between rs4986791 and CAD risk in Asians using the dominant model (CT + TT vs CC: OR = 0.35, 95% CI = 0.21-0.56, p < 0.001), heterozygote contrast (CT vs CC: OR = 0.32, 95% CI = 0.19-0.57, p < 0.001) and allele contrast (T vs C: OR = 0.38, 95% CI = 0.25- 0.58, p < 0.001). No significant association between rs4986791 and CAD was observed among Caucasians. For rs4986790, the results provided no evidence of an association with CAD risk.
Our analysis suggests that rs4986791 is negatively associated with CAD risk in Asians but not in Caucasians. No association between rs4986790 and CAD risk was found.
Toll 样受体 4（TLR4）在冠状动脉粥样硬化斑块的形成和冠状动脉疾病（CAD）的发病机制中起着重要作用。
本研究旨在进行荟萃分析，评估 TLR4 基因中 2 个常见遗传变异（rs4986790 和 rs4986791）与 CAD 易感性之间的关系。
系统检索 Web of Science、Embase、Scopus、PubMed 和万方医学在线。纳入评估 rs4986790 和 rs4986791 与 CAD 风险相关性的病例对照研究。采用比值比（OR）和 95%置信区间（CI）作为评估风险的指标。
文献检索产生了 427 项研究，其中 14 项符合纳入标准，共纳入 13927 名参与者。我们的荟萃分析显示，rs4986791 与亚洲人群 CAD 风险之间存在显著关联，采用显性模型（CT + TT 与 CC：OR = 0.35，95%CI = 0.21-0.56，p < 0.001）、杂合子对比（CT 与 CC：OR = 0.32，95%CI = 0.19-0.57，p < 0.001）和等位基因对比（T 与 C：OR = 0.38，95%CI = 0.25-0.58，p < 0.001）。rs4986791 与高加索人群 CAD 之间无显著相关性。对于 rs4986790，结果未提供与 CAD 风险相关的证据。
我们的分析表明，rs4986791 与亚洲人群 CAD 风险呈负相关，但在高加索人群中无相关性。rs4986790 与 CAD 风险无相关性。
