Bensenor I M
Centro de Pesquisa Clínica e Epidemiológica, Hospital Universitário, Universidade de São Paulo, São Paulo, SP, Brasil.
Departamento de Clínica Médica, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
Braz J Med Biol Res. 2019 Feb 14;52(2):e8417. doi: 10.1590/1414-431X20198417.
Thyroid disorders are common diseases, both in Brazil and worldwide. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) is a prospective cohort study that investigates cardiovascular diseases, diabetes, and associated factors, including non-classical cardiovascular risk factors such as thyroid function. Thyroid function was classified according to thyrotropin stimulating hormone (TSH), free thyroxine (FT4), and use of medication to treat thyroid disorders, after excluding participants who reported use of any medication that could alter the results of the TSH and FT4 tests. All analyses included in this review are cross-sectional using baseline data (2008 to 2010). The results showed an association of subclinical thyroid disorders with biomarkers of subclinical atherosclerosis, measured by carotid intima-media thickness and coronary artery calcium, insulin resistance, metabolic syndrome, and some psychiatric disorders. No association was found with the biomarker of inflammation high-sensitivity C-reactive protein, or changes in pulse wave velocity or heart rate variability.
甲状腺疾病在巴西乃至全球都是常见疾病。巴西成人健康纵向研究（ELSA-Brasil）是一项前瞻性队列研究，旨在调查心血管疾病、糖尿病及相关因素，包括甲状腺功能等非经典心血管危险因素。在排除报告使用过任何可能改变促甲状腺激素（TSH）和游离甲状腺素（FT4）检测结果的药物的参与者后，根据TSH、FT4以及治疗甲状腺疾病的药物使用情况对甲状腺功能进行分类。本综述中包含的所有分析均使用基线数据（2008年至2010年）进行横断面研究。结果显示，亚临床甲状腺疾病与亚临床动脉粥样硬化的生物标志物存在关联，这些生物标志物通过颈动脉内膜中层厚度和冠状动脉钙化、胰岛素抵抗、代谢综合征以及一些精神疾病来衡量。未发现与炎症生物标志物高敏C反应蛋白、脉搏波速度变化或心率变异性存在关联。
