在ELSA-Brasil横断面分析中，亚临床甲状腺功能减退与颈股脉搏波速度之间无关联。
Lack of Association Between Subclinical Hypothyroidism and Carotid-Femoral Pulse Wave Velocity in a Cross-Sectional Analysis of the ELSA-Brasil.
作者信息
Peixoto de Miranda Érique José F, Bittencourt Márcio Sommer, Goulart Alessandra Carvalho, Santos Itamar Souza, Mill José Geraldo, Schmidt Maria Ines, Lotufo Paulo Andrade, Benseñor Isabela J Martins
机构信息
Centro de Pesquisa Clínica, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil.
Departamento de Ciências Fisiológicas, Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brazil.
出版信息
Am J Hypertens. 2017 Jan;30(1):81-87. doi: 10.1093/ajh/hpw117. Epub 2016 Sep 15.
BACKGROUND
There is little available data on carotid-femoral pulse wave velocity (cf-PWV) in subjects with subclinical hypothyroidism (SCH). We aimed to analyze the association between SCH and cf-PWV using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).
METHODS
We included subjects with normal thyroid function (thyrotropin (TSH): 0.4-4.0 mIU/l, and normal free thyroxine (FT4: 0.8-1.9ng/dl) and SCH (TSH > 4.0 mIU/l and normal FT4) evaluated for cf-PWV in a cross-sectional analysis. We excluded individuals using medications that interfere in thyroid function, antihypertensives, or diuretics, and subjects with chronic kidney disease or previous cardiovascular disease. Generalized linear and logistic regression models evaluated cf-PWV as a dependent variable and SCH as an independent variable, adjusted for cardiovascular risk factors.
RESULTS
Of 8,341 subjects (52.3% women), 7,878 (94.4%) were euthyroid and 463 (5.6%) showed SCH. The median age was 50 years (interquartile range: 44-56). The groups differed by age, sex, body mass index, glomerular filtration rate, and C-reactive protein. SCH was not associated with cf-PWV in the full-adjusted linear model (β = -0.039; P = 0.562) and with cf-PWV >75 percentile in the full-adjusted logistic model (odds ratio = 0.94; 95% confidence interval = 0.72-1.22).
CONCLUSION
In a large sample, SCH was not associated with increased cf-PWV.
背景
关于亚临床甲状腺功能减退症（SCH）患者的颈股脉搏波速度（cf-PWV），现有数据较少。我们旨在利用巴西成人健康纵向研究（ELSA-Brasil）的基线数据，分析SCH与cf-PWV之间的关联。
方法
我们纳入了甲状腺功能正常（促甲状腺激素（TSH）：0.4 - 4.0 mIU/l，游离甲状腺素正常（FT4：0.8 - 1.9 ng/dl））和SCH（TSH > 4.0 mIU/l且FT4正常）的受试者，进行cf-PWV的横断面分析。我们排除了使用干扰甲状腺功能药物、抗高血压药或利尿剂的个体，以及患有慢性肾脏病或既往有心血管疾病的受试者。广义线性和逻辑回归模型以cf-PWV为因变量，SCH为自变量，并对心血管危险因素进行了校正。
结果
在8341名受试者（52.3%为女性）中，7878名（94.4%）甲状腺功能正常，463名（5.6%）表现为SCH。中位年龄为50岁（四分位间距：44 - 56岁）。两组在年龄、性别、体重指数、肾小球滤过率和C反应蛋白方面存在差异。在完全校正的线性模型中，SCH与cf-PWV无关（β = -0.039；P = 0.562），在完全校正的逻辑模型中，SCH与cf-PWV > 75百分位数无关（比值比 = 0.94；95%置信区间 = 0.72 - 1.22）。
结论
在一个大样本中，SCH与cf-PWV升高无关。
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