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妊娠期梅毒:一家公立医院的实际情况

Syphilis in Pregnancy: The Reality in a Public Hospital.

作者信息

Torres Rafael Garcia, Mendonça Ana Laura Neves, Montes Grazielle Cezarine, Manzan Jacqueline Jácome, Ribeiro João Ulisses, Paschoini Marina Carvalho

机构信息

Department of Fetal Medicine, Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brazil.

Department of Obstetrics and Gynecology, Universidade de Uberaba, Uberaba, MG, Brazil.

出版信息

Rev Bras Ginecol Obstet. 2019 Feb;41(2):90-96. doi: 10.1055/s-0038-1676569. Epub 2019 Feb 20.

Abstract

OBJECTIVE

The present study assessed epidemiological and obstetrical data from pregnant women with syphilis at the Hospital de Clínicas of the Universidade Federal do Triângulo Mineiro (UFTM, in the Portuguese acronym), describing this disease during pregnancy and its vertical transmission for future healthcare actions.

METHODS

Records from pregnant women who had been admitted to the Obstetrics Department of the Hospital de Clínicas of the UFTM and were diagnosed with syphilis between 2007 and 2016 were reviewed. A standardized form was used to collect epidemiological, obstetric data and outcomes of congenital infection. The present research has been authorized by the Ethics Committee of the institution.

RESULTS

There were 268 women diagnosed with syphilis, with an average age of 23.6 years old. The majority of the patients were from Uberaba. Inadequate prenatal care was observed in 37.9% of the pregnant women. Only 34.2% of the patients completed the treatment according to the guidelines issued by the Ministry of Health of Brazil, and 19.8% of the partners of the patients underwent adequate syphilis treatment; 37 (13.8%) couples (patients and partners) underwent correct treatment. Regarding the obstetric outcomes, 4 (1.5%) patients had a miscarriage and 8 (3.4%) had fetal losses (from the fetal loss group, 7 had no adequate treatment); 61 (25.9%) patients had premature births - this prematurity has been significantly correlated to inadequate or incomplete treatment in 49 (27.9%) patients, compared with 12 (13.0%) patients with premature births and adequate treatment (= 0.006). The average live newborn weight was 2,840 g; 25.3% had a birth weight < 2,500 g; 74.2% had congenital syphilis, a data with heavy correlation to inadequate or incomplete prenatal care, prematurity, and low birth weight.

CONCLUSION

Public awareness policies on adequate prenatal care, intensification of serological screening, and early treatment of syphilis are needed, considering the rise of cases diagnosed during gestation and its potentially preventable deleterious consequences related to congenital transmission.

摘要

目的

本研究评估了米纳斯吉拉斯联邦大学三角地区临床医院(葡萄牙语简称为UFTM)梅毒孕妇的流行病学和产科数据,描述孕期梅毒疾病及其垂直传播情况,以指导未来的医疗保健行动。

方法

回顾了2007年至2016年间入住UFTM临床医院产科且被诊断为梅毒的孕妇记录。使用标准化表格收集流行病学、产科数据以及先天性感染的结局。本研究已获该机构伦理委员会批准。

结果

共有268名女性被诊断为梅毒,平均年龄23.6岁。大多数患者来自乌贝拉巴。37.9%的孕妇产前护理不足。只有34.2%的患者按照巴西卫生部发布的指南完成了治疗,19.8%的患者伴侣接受了充分的梅毒治疗;37对(13.8%)夫妇(患者及其伴侣)接受了正确治疗。关于产科结局,4名(1.5%)患者流产,8名(3.4%)出现胎儿丢失(在胎儿丢失组中,7名未接受充分治疗);61名(25.9%)患者早产——这种早产与49名(27.9%)治疗不足或不完整的患者显著相关,相比之下,12名(13.0%)接受充分治疗的患者出现早产(P = 0.006)。活产新生儿平均体重为2840克;25.3%的新生儿出生体重<2500克;74.2%的新生儿患有先天性梅毒,这一数据与产前护理不足或不完整、早产和低出生体重密切相关。

结论

鉴于孕期确诊病例的增加及其与先天性传播相关的潜在可预防有害后果,需要制定关于充分产前护理、加强血清学筛查和梅毒早期治疗的公众意识政策。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0359/10418253/1e76359ef44b/10-1055-s-0038-1676569-i180250-1.jpg

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