Buzaid Ahmed N, Al-Amri Ali M
Department of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, King Fahd Hospital of the University, Al-Khobar, Saudi Arabia.
Saudi J Med Med Sci. 2017 Sep-Dec;5(3):278-280. doi: 10.4103/sjmms.sjmms_35_16. Epub 2017 Aug 21.
Chronic myelogenous leukemia (CML) is a pluripotent stem cell disease characterized by anemia, granulocytosis and granulocytic immaturity, basophilia, thrombocytosis and splenomegaly. It is associated with a reciprocal chromosomal translocation t (q34; q11), resulting in a breakpoint cluster region-Abelson fusion gene (Philadelphia chromosome). Ophthalmic manifestations as the first and the only presentation of CML in patients are very rare. Ocular lesions in CML patients are frequently asymptomatic, and thus all patients should undergo an eye evaluation at the initial diagnosis. Here, we report a previously healthy 36-year-old Saudi male who initially presented with progressive loss of vision. On examination, he was found to have a bilateral retinal hemorrhage. The investigations revealed findings consistent with CML. The patient was treated with tyrosine kinase inhibitors, and he had complete remission, including full recovery of his vision.
慢性粒细胞白血病（CML）是一种多能干细胞疾病，其特征为贫血、粒细胞增多和粒细胞不成熟、嗜碱性粒细胞增多、血小板增多和脾肿大。它与相互易位的染色体t（q34；q11）相关，导致断裂点簇集区-阿贝尔森融合基因（费城染色体）。眼科表现作为CML患者的首发及唯一表现非常罕见。CML患者的眼部病变通常无症状，因此所有患者在初诊时均应接受眼部评估。在此，我们报告一名36岁既往健康的沙特男性，他最初表现为进行性视力丧失。检查发现他双侧视网膜出血。检查结果显示与CML一致。该患者接受了酪氨酸激酶抑制剂治疗，实现了完全缓解，包括视力完全恢复。
