Granatowicz Austin, Piatek Caroline I, Moschiano Elizabeth, El-Hemaidi Ihab, Armitage Joel D, Akhtari Mojtaba
College of Medicine, University of Nebraska Medical Center, Omaha, USA.
Jane Anne Nohl Division of Hematology and Center for the Study of Blood Diseases, University of Southern California (USC)/Norris Cancer Center, USC University Hospital, Los Angeles, USA.
Korean J Fam Med. 2015 Sep;36(5):197-202. doi: 10.4082/kjfm.2015.36.5.197. Epub 2015 Sep 18.
Chronic myeloid leukemia (CML) accounts for approximately 15% of adult leukemias. Forty percent of patients with CML are asymptomatic, in whom the disease is detected solely based on laboratory abnormalities. Since the introduction of tyrosine kinase inhibitor therapy in 2001, CML has become a chronic disease for the majority of patients. Primary care physicians may be the first to recognize a new diagnosis of CML. In patients with known CML, the primary care physician may be the first to detect disease progression or adverse effects to therapy. This article provides an overview of the clinical presentation, diagnostic approach, and treatment considerations of CML.
慢性髓系白血病（CML）约占成人白血病的15%。40%的CML患者无症状，其疾病仅基于实验室异常而被发现。自2001年引入酪氨酸激酶抑制剂治疗以来，CML对大多数患者而言已成为一种慢性病。初级保健医生可能是最先识别CML新诊断的人。在已知患有CML的患者中，初级保健医生可能是最先发现疾病进展或治疗不良反应的人。本文概述了CML的临床表现、诊断方法及治疗注意事项。
