Al-Khafaji Jaafar F, Sharma Mokshya, Nayeemuddin Khazi, Al-Qaysi Iman A, Al-Mashhadani Arshad A, Taha Mohamed E, Abdalla Abubaker O
Department of Internal Medicine, University of Nevada, Reno, NV, USA.
Department of Biochemistry, University of Baghdad/College of Nursing, Baghdad, Iraq.
J Community Hosp Intern Med Perspect. 2018 Dec 6;9(1):55-58. doi: 10.1080/20009666.2018.1555431. eCollection 2019.
Congenital methemoglobinemia is a rare disease, resulting in increased oxygen affinity and impaired oxygen delivery to the tissues. While there have been studies that have linked acquired methemoglobinemia in almost 79% of leukemia patients, to the best of our knowledge, this is the first case of leukemia development in a patient with congenital methemoglobinemia. Chronic deprivation of oxygen to metabolically active bone marrow can theoretically lead to hematopoietic disorders. It would be interesting to further investigate if presence of congenital methemoglobinemia is a risk factor for developing acute leukemia.
先天性高铁血红蛋白血症是一种罕见疾病，会导致氧亲和力增加以及向组织输送氧气的功能受损。虽然已有研究表明，近79%的白血病患者存在获得性高铁血红蛋白血症，但据我们所知，这是首例先天性高铁血红蛋白血症患者发生白血病的病例。从理论上讲，代谢活跃的骨髓长期缺氧可能导致造血功能紊乱。进一步研究先天性高铁血红蛋白血症的存在是否是发生急性白血病的危险因素将很有意思。
