Yosaee Somaye, Djafarian Kurosh, Esteghamati Alireza, Motevalian Abbas, Shidfar Farzad, Tehrani-Doost Mehdi, Jazayeri Shima
School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
School of Health, Larestan University of Medical Sciences, Larestan, Iran.
Med J Islam Repub Iran. 2018 Oct 1;32:95. doi: 10.14196/mjiri.32.95. eCollection 2018.
Although a growing body of evidence suggests an association between obesity and depressive disorder, the association remains inconclusive. Metabolically healthy obese (MHO) phenotype, defined by favorable lipid profile, and normal insulin sensitivity, blood pressure, may be considered as a possible explanation for these inconsistencies. Accordingly, this study aimed to compare depression score among metabolic unhealthy obese (MUO) and age- and sex-matched healthy controls. In this comparative study including 157 Iranian adults, we assigned participants into three groups (non-obese metabolic healthy group, MHO and MUO) according to the BMI cutoff and MetS criteria. Depressive symptoms were assessed by Beck Depression Inventory. Analysis was done using SPSS version 14.0. All variables are expressed as means ± SD. One-way ANOVA and multiple linear regression were used for data analysis. After adjustment for sex, marital status and educational level, MUO participants had significantly higher Beck depression score (P= 0.036) compared to MHO and non-obese metabolic healthy groups. After adjustment for demographic variables, there was a significant association between waist circumference (β = 0.142, p=0.023), BMI (β= 0.347, p= 0.037), FBS (β= 0.096, p< 0.001), and the number of MetS components (β= 1.71, p= 0.002) with depression score. MHO was a benign phenotype in relation to depression.
尽管越来越多的证据表明肥胖与抑郁症之间存在关联，但这种关联仍无定论。代谢健康肥胖（MHO）表型，由良好的血脂谱、正常的胰岛素敏感性和血压定义，可能是这些不一致现象的一个可能解释。因此，本研究旨在比较代谢不健康肥胖（MUO）组与年龄和性别匹配的健康对照组的抑郁评分。在这项纳入157名伊朗成年人的比较研究中，我们根据BMI临界值和代谢综合征（MetS）标准将参与者分为三组（非肥胖代谢健康组、MHO组和MUO组）。通过贝克抑郁量表评估抑郁症状。使用SPSS 14.0版本进行分析。所有变量均以均值±标准差表示。采用单因素方差分析和多元线性回归进行数据分析。在对性别、婚姻状况和教育水平进行调整后，与MHO组和非肥胖代谢健康组相比，MUO组参与者的贝克抑郁评分显著更高（P = 0.036）。在对人口统计学变量进行调整后，腰围（β = 0.142，p = 0.023）、BMI（β = 0.347，p = 0.037）、空腹血糖（FBS，β = 0.096，p < 0.001）以及MetS组分数量（β = 1.71，p = 0.002）与抑郁评分之间存在显著关联。就抑郁症而言，MHO是一种良性表型。
