Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Division of Paediatric Endocrinology, Khoo Teck Puat-National University Children's Medical Institute, National University Hospital, National University Health System, Singapore, Singapore.
Pediatr Res. 2023 Sep;94(3):1089-1097. doi: 10.1038/s41390-023-02572-8. Epub 2023 Mar 22.
Obesity and obesity-related morbidities are associated with poor psychosocial adjustment and health-related quality of life (HRQoL). This study aims to examine HRQoL and psychosocial outcomes in children with metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO), and the effects of familial health on these outcomes.
Four hundred and six children with BMI for age ≥ 97th percentile were classified as having MHO and MUO based on the absence or presence of metabolic abnormalities. HRQoL and psychosocial outcomes were assessed using validated questionnaires such as PedsQL and DASS-21.
There were no significant differences in HRQoL and psychosocial outcomes between children with MHO and children with MUO. Children with MUO and prior knowledge of existing metabolic conditions reported significantly lower total HRQoL (71.18 ± 17.42 vs. 75.34 ± 15.33), and higher depression (12.16 ± 11.80 vs. 8.95 ± 8.52) and stress (12.11 ± 8.21 vs. 10.04 ± 7.92) compared to children with MHO. Children with MUO who had fathers with metabolically unhealthy phenotype reported significantly lower total HRQoL (72.41 ± 15.67 vs. 76.82 ± 14.91) compared to children with MUO who had fathers with metabolically healthy phenotype.
Prior knowledge of existing metabolic abnormalities was associated with poorer HRQoL and mental health in children with obesity. Paternal metabolic health status influenced HRQoL in children with MUO.
First study that compared health-related quality of life (HRQoL) and psychosocial outcomes between children with metabolically healthy obesity (MHO) and children with metabolically unhealthy obesity (MUO). No significant differences in HRQoL and psychosocial outcomes between children with metabolically healthy obesity (MHO) and children with metabolically unhealthy obesity (MUO). Children with MUO who had prior knowledge of existing metabolic conditions reported lower HRQoL, higher depression and stress compared to children with MHO. Paternal metabolic health status was found to influence HRQoL in children with MUO. Mental health support intervention with paternal involvement should be provided for children with MUO.
肥胖症和与肥胖相关的多种疾病与较差的社会心理适应和健康相关生活质量（HRQoL）有关。本研究旨在研究代谢健康肥胖症（MHO）和代谢不健康肥胖症（MUO）儿童的 HRQoL 和心理社会结局，以及家族健康对这些结局的影响。
根据是否存在代谢异常，将 406 名 BMI 年龄≥第 97 百分位的儿童归类为 MHO 和 MUO。使用经过验证的问卷（如 PedsQL 和 DASS-21）评估 HRQoL 和心理社会结局。
MHO 儿童和 MUO 儿童之间的 HRQoL 和心理社会结局没有差异。有 MUO 和已知代谢异常的儿童报告的总 HRQoL 明显较低（71.18±17.42 与 75.34±15.33），抑郁（12.16±11.80 与 8.95±8.52）和压力（12.11±8.21 与 10.04±7.92）更高。与 MHO 儿童相比，MUO 儿童的父亲表现出代谢不健康表型，报告的总 HRQoL 明显较低（72.41±15.67 与 76.82±14.91）。
已知存在代谢异常与肥胖儿童的 HRQoL 和心理健康较差有关。父亲的代谢健康状况影响 MUO 儿童的 HRQoL。
这是第一项比较代谢健康肥胖症（MHO）和代谢不健康肥胖症（MUO）儿童之间 HRQoL 和心理社会结局的研究。MHO 儿童和 MUO 儿童之间的 HRQoL 和心理社会结局没有差异。有 MUO 和已知代谢异常的儿童报告的 HRQoL 较低，抑郁和压力较高，与 MHO 儿童相比。发现 MUO 儿童的父亲代谢健康状况影响其 HRQoL。应提供包含父亲参与的 MUO 儿童心理健康支持干预。
